selected publications
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academic article
- GPER modulators: Opportunity Nox on the heels of a class Akt.. The Journal of steroid biochemistry and molecular biology. :-. 2017
- Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.. The Journal of steroid biochemistry and molecular biology. :-. 2017
- Obligatory role for GPER in cardiovascular aging and disease.. Science signaling. 9:-. 2016
- Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.. Proceedings of the National Academy of Sciences of the United States of America. :-. 2016
- GPER mediates the age-dependent upregulation of the myocardial endothelin system.. Life sciences. :-. 2016
- GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism.. Methods in molecular biology (Clifton, N.J.). 1366:489-502. 2016
- Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.. PloS one. 11:-. 2016
- G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity.. The Journal of endocrinology. :-. 2015
- Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging.. Age (Dordrecht, Netherlands). 37:-. 2015
- International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.. Pharmacological reviews. 67:505-540. 2015
- What have we learned about GPER function in physiology and disease from knockout mice?. The Journal of steroid biochemistry and molecular biology. :-. 2015
- Effects of Atrazine on Estrogen Receptor α- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.. Environmental health perspectives. :-. 2015
- Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER.. BMC cancer. 15:-. 2015
- Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity.. The Journal of biological chemistry. 289:32481-32487. 2014
- Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis. 2014
- Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches.. Obstetrics and gynecology international. 2014:-. 2014
- Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries.. Life sciences. :-. 2014
- Estrogen biology: new insights into GPER function and clinical opportunities.. Molecular and cellular endocrinology. 389:71-83. 2014
- G Protein-coupled Estrogen Receptor Protects from Atherosclerosis.. Scientific reports. 4:-. 2014
- G protein-coupled estrogen receptor (GPER) regulates mammary tumorigenesis and metastasis.. Molecular cancer research : MCR. :-. 2014
- GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast.. Hormones & cancer. 5:146-160. 2014
- GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding.. Molecular cancer research : MCR. :-. 2014
- Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. 2014
- Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation.. Journal of cardiovascular pharmacology. 62:22-25. 2013
- Functional heterogeneity of NADPH oxidase-mediated contractions to endothelin with vascular aging.. Life sciences. :-. 2013
- G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth.. Obstetrics and gynecology international. 2013:-. 2013
- GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state.. Endocrinology. 154:4136-4145. 2013
- Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. 2013
- Regulation of vascular smooth muscle tone by adipose-derived contracting factor. 2013
- The Concise Guide to PHARMACOLOGY 2013/14: overview.. British journal of pharmacology. 170:1449-1458. 2013
- The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions.. Journal of immunotherapy (Hagerstown, Md. : 1997). 36:190-196. 2013
- Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction.. Hypertension. 59:507-512. 2012
- G protein-coupled estrogen receptor: A new therapeutic target in stroke and traumatic brain/spinal cord injury?*.. Critical care medicine. 40:3323-3325. 2012
- GPER regulates endothelin-dependent vascular tone and intracellular calcium.. Life sciences. 91:623-627. 2012
- Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.. PloS one. 7:-. 2012
- Testosterone and secondary hypertension: new pieces to the puzzle.. Hypertension. 59:1101-1103. 2012
- Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle.. American journal of physiology. Endocrinology and metabolism. 301:E882-E888. 2011
- Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.. The Journal of steroid biochemistry and molecular biology. 127:358-366. 2011
- Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.. Immunology. 134:93-106. 2011
- Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells.. Endocrinology. 152:3030-3039. 2011
- Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms.. International journal of surgical pathology. 19:588-596. 2011
- The G-protein-coupled estrogen receptor GPER in health and disease.. Nature reviews. Endocrinology. 7:715-726. 2011
- GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer.. Breast cancer research and treatment. 123:51-58. 2010
- Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.. Organic & biomolecular chemistry. 8:2252-2259. 2010
- Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents.. ACS chemical biology. 5:681-690. 2010
- The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.. Cancer research. 70:1184-1194. 2010
- Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.. Journal of biomolecular screening. 14:596-609. 2009
- Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 75:253-263. 2009
- Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.. Journal of neuroscience research. 87:1610-1619. 2009
- GPR30 predicts poor survival for ovarian cancer.. Gynecologic oncology. 114:465-471. 2009
- High-content screening: flow cytometry analysis.. Methods in molecular biology (Clifton, N.J.). 486:151-165. 2009
- In vivo effects of a GPR30 antagonist.. Nature chemical biology. 5:421-427. 2009
- Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.. Circulation research. 104:288-291. 2009
- A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 73:390-399. 2008
- Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation.. Nuclear medicine and biology. 35:673-678. 2008
- Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.. Annual review of physiology. 70:165-190. 2008
- GPR30: a novel therapeutic target in estrogen-related disease.. Trends in pharmacological sciences. 29:116-123. 2008
- Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 49:978-986. 2008
- The ins and outs of GPR30: a transmembrane estrogen receptor.. The Journal of steroid biochemistry and molecular biology. 109:350-353. 2008
- Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization.. Molecular biology of the cell. 18:1410-1420. 2007
- Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.. The Journal of endocrinology. 193:311-321. 2007
- G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.. Cancer research. 67:1859-1866. 2007
- Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides.. Analytical biochemistry. 371:10-20. 2007
- Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.. Advances in protein chemistry. 74:95-135. 2007
- Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform.. Nature protocols. 1:59-66. 2006
- Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 69:326-334. 2006
- Virtual and biomolecular screening converge on a selective agonist for GPR30.. Nature chemical biology. 2:207-212. 2006
- High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.. Journal of biomolecular screening. 10:374-382. 2005
- Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists.. Molecular pharmacology. 68:1301-1310. 2005
- Post-high-throughput screening analysis: an empirical compound prioritization scheme.. Journal of biomolecular screening. 10:419-426. 2005
- Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.. The Journal of biological chemistry. 279:32435-32443. 2004
- Flow cytometry for high-throughput, high-content screening.. Current opinion in chemical biology. 8:392-398. 2004
- N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation.. The Journal of biological chemistry. 279:45175-45184. 2004
- FRET detection of cellular alpha4-integrin conformational activation.. Biophysical journal. 85:3951-3962. 2003
- Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.. Molecular pharmacology. 64:1227-1238. 2003
- Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.. Bioconjugate chemistry. 22:1682-1689.
- The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function.
- Emerging roles of GPER in diabetes and atherosclerosis.. Trends in endocrinology and metabolism: TEM. 185-192. 2015