Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Academic Article uri icon

start page

  • 2252

end page

  • 2259

abstract

  • The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

date/time value

  • 2010

Digital Object Identifier (DOI)

  • 10.1039/c001307b

PubMed Identifier

  • 20401403

volume

  • 8

number

  • 9

keywords

  • Cyclopentanes
  • Molecular Structure
  • Quinolines
  • Receptors, G-Protein-Coupled
  • Stereoisomerism
  • Structure-Activity Relationship