- Microcirculatory Society Member 2005 -
- American Society of Pharmacology and Experimental Therapuetics Member, Cardiovascular Division officer 1998 -
- American Heart Association Fellow 1993 -
- American Physiological Society Fellow, Cardiovascular Division 1993 -
My primary research interests are vascular physiology, hypertension and blood pressure control. My current research focuses on altered signal transduction in vascular cells during the development and maintenance of hypertension. This involves studies in vascular smooth muscle cells, endothelial cells and arterial segments. The long-term goal of these investigations is elucidation of the mechanisms responsible for elevated vascular contractility in hypertension and the development of pharmacological tools to reverse this hypersensitivity.
A major emphasis is investigating vascular effects of sleep apnea. We have developed a rat model of sleep apnea by exposing animals to intermittent hypoxia during their sleep period. Using this model, we have determined that the vasoactive peptide endothelin appears to initiate sustained hypertension (Kanagy et al 2001). We have also determined that 14 days of intermittent hypoxia initiates profound vascular changes that alter both endothelial function and vascular smooth muscle cell responses to endothelin. Ongoing studies are investigating the role of reactive oxygen species in these changes and deciphering the molecular mechanisms leading to augmented vasoconstriction to the endogenous peptide, endothelin.
A second ongoing project is investigating the cardiovascular effects of the environmental pollutant, diesel exhaust. We have found that even a short exposure to diesel exhaust causes profound alterations in coronary artery function and that repeated exposures initiate systemic alterations in both cardiac and vascular function.
We have recently been studying the contribution of hydrogen sulfide to the control of blood pressure and blood flow. These studies are exploring the site of synthesis of hydrogen sulfide, the mechanism of action in the vascular wall and the effect of intermittent hypoxia on the pathway.
- R01 HL123301 “Hydrogen sulfide regulation of vascular tone and blood pressure.” Principal Investigator 2014 - 2018
- Dialysis Clinics Incorporated Research Award PI 2014 - 2017
- R41HL121871 “Transdermal H2S-sensing device for monitoring peripheral artery disease.” co-PI 2014 - 2016
- HL82799 Role of endothelin in sleep apnea induced hypertension in rats. PI 2007 - 2012
principal investigator on
- My teaching is in three areas, graduate student mentoring, graduate student classroom teaching, medical student phase one teaching. In both classroom settings, I lecture on renal physiology. These are part of team teaching courses. In addition, I participate in graduate courses on Ion Channel Function and Cardio-pulmonary physiology with occasional guest lectures on renal toxicology in the School of Pharmacy. My graduate mentoring has included mentoring 8 PhD students and several post-doctoral fellows.
collection or series editor for
- Circulation Research Journal 2008 -
- Journal of Cardiovascular Research Journal 2008 -
- National Heart Lung and Blood Institutes Research Proposal 2003 -
- Journal of Pharmacology and Experimental Therapeutics Journal 1999 -
- American journal of physiology. Heart and circulatory physiology Journal 1998 -
- Hypertension Journal 1995 -
service to the profession
- National Institutes of Health Peer Review Committee 2010 -