head of
- Biomedical Sciences Graduate Program Director 2017 - 2020
- Signature Program in Cardiovascular and Metabolic Disease Leader 2008 - 2017
- Contact Info
- 505-272-8814
- Websites
Kanagy, Nancy Professor and Department Chair
Positions
- Professor, Department of Cell Biology and Physiology , School of Medicine
- Chair, Department of Cell Biology and Physiology , School of Medicine 2020 -
- Affiliation
- Publications
- Research
- Teaching
- Service
- Contact
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Affiliation
member of
- National Institute of Heart, Lung and Blood Peer Review Panel 2016 -
- Microcirculatory Society Member 2005 -
- American Society of Pharmacology and Experimental Therapuetics Member, Cardiovascular Division officer 1998 -
- American Heart Association Fellow 1993 -
- American Physiological Society Fellow, Cardiovascular Division 1993 -
has collaborator
- Gonzalez Bosc, Laura V Associate Professor
- Jernigan, Nikki Professor
- Prossnitz, Eric Professor
- Resta, Thomas Faculty Member
- Walker, Benjimen Professor
- Walker, Mary Professor and Regents' Professor
- Ward, Heather H Assistant Professor
Publications
selected publications
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academic article
- A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea.. American journal of physiology. Renal physiology. :-. 2019
- Intermittent hypoxia exacerbates increased blood pressure in rats with chronic kidney disease.. American journal of physiology. Renal physiology. 315:F927-F941. 2018
- Vascular biology of hydrogen sulfide.. American journal of physiology. Cell physiology. 312:C537-C549. 2017
- NFAT regulation of cystathionine γ-lyase expression in endothelial cells is impaired in rats exposed to intermittent hypoxia.. American journal of physiology. Heart and circulatory physiology. 312:H791-H799. 2017
- Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels.. American journal of physiology. Heart and circulatory physiology. 311:H1437-H1444. 2016
- Intermittent Hypoxia in Rats Reduces Activation of Ca2+ Sparks in Mesenteric Arteries.. American journal of physiology. Heart and circulatory physiology. :-. 2015
- Endothelin-1-induced vasoconstriction does not require intracellular Ca²⁺ waves in arteries from rats exposed to intermittent hypoxia.. American journal of physiology. Heart and circulatory physiology. 306:H667-H673. 2014
- Intermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity. Vascular pharmacology. 60:17-24. 2014
- Modulation of hydrogen sulfide by vascular hypoxia.. Hypoxia (Auckland, N.Z.). 2:117-126. 2014
- Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca²⁺-activated K⁺ channels and smooth muscle Ca²⁺ sparks.. American journal of physiology. Heart and circulatory physiology. 304:H1446-H1454. 2013
- Phosphoinositide-dependent kinase-1 and protein kinase Cδ contribute to endothelin-1 constriction and elevated blood pressure in intermittent hypoxia.. The Journal of pharmacology and experimental therapeutics. 344:68-76. 2013
- Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction.. Hypertension. 59:507-512. 2012
- GPER regulates endothelin-dependent vascular tone and intracellular calcium.. Life sciences. 91:623-627. 2012
- Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(2+)-activated potassium channels.. Circulation research. 108:1439-1447. 2011
- Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. 2011
- Formation of vascular S-nitrosothiols and plasma nitrates/nitrites following inhalation of diesel emissions.. Journal of toxicology and environmental health. Part A. 74:828-837. 2011
- Increased adiposity does not exacerbate impaired vasodilation in rats exposed to eucapnic intermittent hypoxia.. Respiration; international review of thoracic diseases. 81:47-56. 2011
- Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species.. Journal of applied physiology (Bethesda, Md. : 1985). 111:980-988. 2011
- Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles.. Environmental health perspectives. 119:98-103. 2011
- NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.. American journal of physiology. Heart and circulatory physiology. 299:H356-H363. 2010
- An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice.. Biochemical pharmacology. 80:197-204. 2010
- Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.. The Journal of pharmacology and experimental therapeutics. 334:753-760. 2010
- Mechanisms of intermittent hypoxia induced hypertension.. Journal of cellular and molecular medicine. 14:3-17. 2010
- Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions.. American journal of physiology. Regulatory, integrative and comparative physiology. 297:R640-R647. 2009
- Rat strain differences in pulmonary artery smooth muscle Ca(2+) entry following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 16:603-614. 2009
- Vascular effects of intermittent hypoxia.. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 50:282-288. 2009
- Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.. American journal of physiology. Lung cellular and molecular physiology. 295:L688-L697. 2008
- Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.. American journal of physiology. Heart and circulatory physiology. 295:H434-H440. 2008
- NFATc3 is required for intermittent hypoxia-induced hypertension.. American journal of physiology. Heart and circulatory physiology. 294:H2382-H2390. 2008
- Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude.. Hypertension. 51:803-809. 2008
- Eucapnic intermittent hypoxia augments endothelin-1 vasoconstriction in rats: role of PKCdelta.. American journal of physiology. Heart and circulatory physiology. 294:H920-H927. 2008
- Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity.. Journal of applied physiology (Bethesda, Md. : 1985). 104:110-118. 2008
- ROK contribution to endothelin-mediated contraction in aorta and mesenteric arteries following intermittent hypoxia/hypercapnia in rats.. American journal of physiology. Heart and circulatory physiology. 293:H2911-H2918. 2007
- Reactive oxygen species contribute to sleep apnea-induced hypertension in rats.. American journal of physiology. Heart and circulatory physiology. 293:H2971-H2976. 2007
- Loss of alpha2B-adrenoceptors increases magnitude of hypertension following nitric oxide synthase inhibition.. American journal of physiology. Heart and circulatory physiology. 291:H2403-H2408. 2006
- Alpha(2)-adrenergic receptor signalling in hypertension.. Clinical science (London, England : 1979). 109:431-437. 2005
- Reduced functional expression of K(+) channels in vascular smooth muscle cells from rats made hypertensive with N{omega}-nitro-L-arginine.. American journal of physiology. Heart and circulatory physiology. 289:H1284-H1290. 2005
- Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension.. Hypertension. 45:705-709. 2005
- Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function.. American journal of physiology. Heart and circulatory physiology. 287:H2394-H2401. 2004
- 17-beta estradiol attenuates hypoxic induction of HIF-1alpha and erythropoietin in Hep3B cells.. Journal of cardiovascular pharmacology. 44:93-100. 2004
- 17-beta estradiol independently regulates erythropoietin synthesis and NOS activity during hypoxia.. Journal of cardiovascular pharmacology. 43:312-317. 2004
- Erythropoietin administration in vivo increases vascular nitric oxide synthase expression.. Journal of cardiovascular pharmacology. 42:527-533. 2003
- Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure.. Toxicology and applied pharmacology. 193:177-187. 2003
- Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.. American journal of physiology. Heart and circulatory physiology. 284:H309-H316. 2003
- Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta.. American journal of physiology. Heart and circulatory physiology. 283:H1361-H1369. 2002
- Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.. American journal of physiology. Heart and circulatory physiology. 283:H1673-H1680. 2002
- 17Beta-estradiol decreases hypoxic induction of erythropoietin gene expression.. American journal of physiology. Regulatory, integrative and comparative physiology. 283:R496-R504. 2002
- Vascular smooth muscle cell membrane depolarization after NOS inhibition hypertension.. American journal of physiology. Heart and circulatory physiology. 282:H1648-H1655. 2002
- Ca2+ influx mediates enhanced alpha2-adrenergic contraction in aortas from rats treated with NOS inhibitor.. American journal of physiology. Heart and circulatory physiology. 281:H2233-H2240. 2001
- 17beta-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta.. American journal of physiology. Lung cellular and molecular physiology. 280:L555-L564. 2001
- Role of endothelin in intermittent hypoxia-induced hypertension.. Hypertension. 37:511-515. 2001
- Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.. American journal of physiology. Lung cellular and molecular physiology. 280:L88-L97. 2001
- Laboratory demonstration of vascular smooth muscle function using rat aortic ring segments.. Advances in physiology education. 24:13-21. 2000
- Endothelium-Independent Relaxation of Vascular Smooth Muscle by 17beta-Estradiol.. Journal of cardiovascular pharmacology and therapeutics. 4:227-234. 1999
- Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. 1998
- Increased vascular responsiveness to alpha 2-adrenergic stimulation during NOS inhibition-induced hypertension. 1997
- Decreased sensitivity to vasoconstrictors in aortic rings after acute exposure to nitric oxide. 1996
- Arachidonate metabolites and serotonin contraction of femoral arteries from DOCA-salt hypertensive rats.. Blood pressure. 5:113-120. 1996
- Increased responsiveness and decreased expression of G proteins in deoxycorticosterone hypertension.. Hypertension. 27:740-745. 1996
- Nitric oxide regulation of ADP-ribosylation of G proteins in hypertension.. Medical hypotheses. 44:159-164. 1995
- Recycling and buffering of intracellular calcium in vascular smooth muscle from genetically hypertensive rats. 1994
- Enhanced vascular reactivity to mastoparan, a G protein activator, in genetically hypertensive rats.. Hypertension. 23:946-950. 1994
- Losartan prevents salt-induced hypertension in reduced renal mass rats.. The Journal of pharmacology and experimental therapeutics. 265:1131-1136. 1993
- Obese Zucker rats are normotensive on normal and increased sodium intake.. Hypertension. 19:I90-I95. 1992
- Role of aldosterone in angiotensin II-induced hypertension in rats. 1990
- Chronic hypertension produced by infusion of endothelin in rats.. Hypertension. 15:729-733. 1990
collection or series editor for
- American journal of physiology. Heart and circulatory physiology (Journal) 2011 -
Research
research overview
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My primary research interests are vascular physiology, hypertension and blood pressure control. My current research focuses on altered signal transduction in vascular cells during the development and maintenance of hypertension. This involves studies in vascular smooth muscle cells, endothelial cells and arterial segments. The long-term goal of these investigations is elucidation of the mechanisms responsible for elevated vascular contractility in hypertension and the development of pharmacological tools to reverse this hypersensitivity.
A major emphasis is investigating vascular effects of sleep apnea. We have developed a rat model of sleep apnea by exposing animals to intermittent hypoxia during their sleep period. Using this model, we have determined that the vasoactive peptide endothelin appears to initiate sustained hypertension (Kanagy et al 2001). We have also determined that 14 days of intermittent hypoxia initiates profound vascular changes that alter both endothelial function and vascular smooth muscle cell responses to endothelin. Ongoing studies are investigating the role of reactive oxygen species in these changes and deciphering the molecular mechanisms leading to augmented vasoconstriction to the endogenous peptide, endothelin.A second ongoing project is investigating the cardiovascular effects of the environmental pollutant, diesel exhaust. We have found that even a short exposure to diesel exhaust causes profound alterations in coronary artery function and that repeated exposures initiate systemic alterations in both cardiac and vascular function.
We have recently been studying the contribution of hydrogen sulfide to the control of blood pressure and blood flow. These studies are exploring the site of synthesis of hydrogen sulfide, the mechanism of action in the vascular wall and the effect of intermittent hypoxia on the pathway.
principal investigator on
investigator on
other research activities
- R01 HL123301 “Hydrogen sulfide regulation of vascular tone and blood pressure.” Principal Investigator 2014 - 2018
- Dialysis Clinics Incorporated Research Award PI 2014 - 2017
- R41HL121871 “Transdermal H2S-sensing device for monitoring peripheral artery disease.” co-PI 2014 - 2016
- HL82799 Role of endothelin in sleep apnea induced hypertension in rats. PI 2007 - 2012
Teaching
teaching overview
- My teaching is in three areas, graduate student mentoring, graduate student classroom teaching, medical student phase one teaching. In both classroom settings, I lecture on renal physiology. These are part of team teaching courses. In addition, I participate in graduate courses on Ion Channel Function and Cardio-pulmonary physiology with occasional guest lectures on renal toxicology in the School of Pharmacy. My graduate mentoring has included mentoring 8 PhD students and several post-doctoral fellows.
Service
reviewer of
- Circulation Research (Journal) 2008 -
- Journal of Cardiovascular Research (Journal) 2008 -
- National Heart Lung and Blood Institutes (Research Proposal) 2003 -
- Journal of Pharmacology and Experimental Therapeutics (Journal) 1999 -
- American journal of physiology. Heart and circulatory physiology (Journal) 1998 -
- Hypertension (Journal) 1995 -
professional service activities
- National Institutes of Health Peer Review Committee 2010 -
Contact
full name
- Nancy L Kanagy