has collaborator
- Gonzalez Bosc, Laura V Associate Professor
- Kanagy, Nancy Professor and Department Chair
- Contact Info
Jernigan, Nikki Professor
Positions
Research Areas
- Hypertension (LCSH)
- Pulmonary circulation (LCSH)
- Vascular Physiology
- Affiliation
- Publications
- Background
- Contact
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Affiliation
Publications
selected publications
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academic article
- Redox Regulation of Ion Channels and Receptors in Pulmonary Hypertension.. Antioxidants & redox signaling. :-. 2019
- Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 314:H1011-H1021. 2018
- Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca2+ entry.. American journal of physiology. Heart and circulatory physiology. 314:H359-H369. 2018
- RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia.. American journal of physiology. Cell physiology. 314:C166-C176. 2018
- Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension.. Pulmonary circulation. 8:-. 2018
- Cholesterol Regulation of Pulmonary Endothelial Calcium Homeostasis.. Current topics in membranes. 82:53-91. 2018
- Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. 2018
- Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 313:H828-H838. 2017
- Reduced membrane cholesterol limits pulmonary endothelial Ca(2+) entry after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 312:H1176-H1184. 2017
- Altered Redox Balance in the Development of Chronic Hypoxia-induced Pulmonary Hypertension.. Advances in experimental medicine and biology. 967:83-103. 2017
- Contribution of reactive oxygen species to the pathogenesis of pulmonary arterial hypertension. 2017
- ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells.. American journal of physiology. Lung cellular and molecular physiology. 311:L48-L58. 2016
- PICK1/Calcineurin Suppress ASIC1-mediated Ca2+ Entry in Rat Pulmonary Arterial Smooth Muscle Cells.. American journal of physiology. Cell physiology. :-. 2015
- Mechanisms of NFATc3 activation by increased superoxide and reduced hydrogen peroxide in pulmonary arterial smooth muscle.. American journal of physiology. Cell physiology. 307:C928-C938. 2014
- Smooth muscle acid sensing ion channel 1: Pathophysiologic implication in hypoxic pulmonary hypertension.. Experimental physiology. :-. 2014
- Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 307:L419-L430. 2014
- Calcium homeostasis and sensitization in pulmonary arterial smooth muscle.. Microcirculation (New York, N.Y. : 1994). 21:259-271. 2014
- Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.. American journal of physiology. Heart and circulatory physiology. 306:H41-H52. 2014
- Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2.. Antioxidants & redox signaling. 18:1777-1788. 2013
- Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor-dependent vasoconstriction.. American journal of physiology. Cell physiology. 302:C931-C940. 2012
- Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species.. Journal of applied physiology (Bethesda, Md. : 1985). 111:980-988. 2011
- Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. 2010
- Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension.. Advances in experimental medicine and biology. 661:355-373. 2010
- ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry. 2009
- Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 295:L515-L529. 2008
- Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 290:L517-L525. 2006
- Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling.. American journal of physiology. Lung cellular and molecular physiology. 287:L1220-L1229. 2004
- Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 287:L801-L808. 2004
- Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 286:L947-L955. 2004
- Pulmonary PKG-1 is upregulated following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 285:L634-L642. 2003
- Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation.. American journal of physiology. Lung cellular and molecular physiology. 282:L1366-L1375. 2002
Background
advisee of
-
graduate advising relationship
- Resta, Thomas, Ph.D. candidacy, - 2004
-
postdoc or fellow advising relationship
- Resta, Thomas, 2006 - 2008
Contact
full name
- Nikki L Jernigan