has collaborator
- Gonzalez Bosc, Laura V Associate Professor
- Kanagy, Nancy Professor and Department Chair
- Contact Info
- Websites
Resta, Thomas Faculty Member
Positions
- Senior Associate Dean for Research Education, School of Medicine 2020 -
The overall goal of my research program is to identify vascular smooth muscle and endothelial cell signaling mechanisms that mediate vasoconstriction and arterial remodeling in hypoxia-associated pulmonary hypertension.
Research Areas
- Hypertension (LCSH)
- Vascular Physiology
- Affiliation
- Publications
- Research
- Teaching
- Service
- Background
- Contact
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Affiliation
Publications
selected publications
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academic article
- Maternal Decision-Making and Uptake of Health Services for the Prevention of Mother-to-Child HIV Transmission: A Secondary Analysis.. Maternal and child health journal. 23:30-38. 2019
- Redox Regulation of Ion Channels and Receptors in Pulmonary Hypertension.. Antioxidants & redox signaling. :-. 2019
- Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 314:H1011-H1021. 2018
- Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca2+ entry.. American journal of physiology. Heart and circulatory physiology. 314:H359-H369. 2018
- RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia.. American journal of physiology. Cell physiology. 314:C166-C176. 2018
- Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension.. Pulmonary circulation. 8:-. 2018
- Cholesterol Regulation of Pulmonary Endothelial Calcium Homeostasis.. Current topics in membranes. 82:53-91. 2018
- Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. 2018
- Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 313:H828-H838. 2017
- Reduced membrane cholesterol limits pulmonary endothelial Ca(2+) entry after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 312:H1176-H1184. 2017
- Central Role of T Helper 17 Cells in Chronic Hypoxia-Induced Pulmonary Hypertension.. American journal of physiology. Lung cellular and molecular physiology. :-. 2017
- Altered Redox Balance in the Development of Chronic Hypoxia-induced Pulmonary Hypertension.. Advances in experimental medicine and biology. 967:83-103. 2017
- Contribution of reactive oxygen species to the pathogenesis of pulmonary arterial hypertension. 2017
- PICK1/Calcineurin Suppress ASIC1-mediated Ca2+ Entry in Rat Pulmonary Arterial Smooth Muscle Cells.. American journal of physiology. Cell physiology. :-. 2015
- Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 307:L419-L430. 2014
- Calcium homeostasis and sensitization in pulmonary arterial smooth muscle.. Microcirculation (New York, N.Y. : 1994). 21:259-271. 2014
- Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.. American journal of physiology. Heart and circulatory physiology. 306:H41-H52. 2014
- Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2.. Antioxidants & redox signaling. 18:1777-1788. 2013
- NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice.. American journal of physiology. Lung cellular and molecular physiology. 304:L613-L625. 2013
- Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor-dependent vasoconstriction.. American journal of physiology. Cell physiology. 302:C931-C940. 2012
- Role for PKC? in enhanced endothelin-1-induced pulmonary vasoconstrictor reactivity following intermittent hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 301:L745-L754. 2011
- Altered membrane lipid domains limit pulmonary endothelial calcium entry following chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 301:H1331-H1340. 2011
- Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species.. Journal of applied physiology (Bethesda, Md. : 1985). 111:980-988. 2011
- NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. 2011
- Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.. The Journal of pharmacology and experimental therapeutics. 334:753-760. 2010
- Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. 2010
- Mechanisms of intermittent hypoxia induced hypertension.. Journal of cellular and molecular medicine. 14:3-17. 2010
- Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension.. Advances in experimental medicine and biology. 661:355-373. 2010
- ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry. 2009
- Rat strain differences in pulmonary artery smooth muscle Ca(2+) entry following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 16:603-614. 2009
- Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.. Circulation research. 104:288-291. 2009
- Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.. American journal of physiology. Lung cellular and molecular physiology. 294:L797-L806. 2008
- Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity.. Journal of applied physiology (Bethesda, Md. : 1985). 104:110-118. 2008
- Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 15:473-484. 2008
- Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 295:L515-L529. 2008
- Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats.. American journal of physiology. Lung cellular and molecular physiology. 293:L1135-L1142. 2007
- Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 290:L517-L525. 2006
- Kidney disease among the Zuni Indians: the Zuni Kidney Project.. Kidney international. Supplement. :S126-S131. 2005
- Pressure-induced smooth muscle cell depolarization in pulmonary arteries from control and chronically hypoxic rats does not cause myogenic vasoconstriction. 2005
- Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling.. American journal of physiology. Lung cellular and molecular physiology. 287:L1220-L1229. 2004
- Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries.. American journal of physiology. Heart and circulatory physiology. 287:H2677-H2686. 2004
- Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats. 2004
- Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 287:L801-L808. 2004
- 17-beta estradiol attenuates hypoxic induction of HIF-1alpha and erythropoietin in Hep3B cells.. Journal of cardiovascular pharmacology. 44:93-100. 2004
- Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 286:L947-L955. 2004
- 17-beta estradiol independently regulates erythropoietin synthesis and NOS activity during hypoxia.. Journal of cardiovascular pharmacology. 43:312-317. 2004
- Pulmonary PKG-1 is upregulated following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 285:L634-L642. 2003
- Prevalence of hematuria among Zuni Indians with and without diabetes: The Zuni kidney Project. 2003
- Epidemic of diabetic and nondiabetic renal disease among the Zuni Indians: the Zuni Kidney Project.. Journal of the American Society of Nephrology : JASN. 14:1320-1329. 2003
- Prevalence of diabetes is higher among female than male Zuni indians. 2003
- Laboratory demonstration of baroreflex control of heart rate in conscious rats.. Advances in physiology education. 26:309-316. 2002
- Rate of NO scavenging alters effects of recombinant hemoglobin solutions on pulmonary vasoreactivity. 2002
- 17Beta-estradiol decreases hypoxic induction of erythropoietin gene expression.. American journal of physiology. Regulatory, integrative and comparative physiology. 283:R496-R504. 2002
- Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression.. American journal of physiology. Lung cellular and molecular physiology. 283:L86-L93. 2002
- Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation.. American journal of physiology. Lung cellular and molecular physiology. 282:L1366-L1375. 2002
- Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.. American journal of physiology. Lung cellular and molecular physiology. 280:L88-L97. 2001
- Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. 1998
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website
Research
research overview
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- Mechanisms of chronic hypoxia- and intermittent hypoxia-induced pulmonary hypertension
- Pulmonary vasoreactivity
- Endothelial regulation of vascular tone
- Regulation of vascular smooth muscle contraction by reactive oxygen species, nitric oxide, RhoA and PKC signaling
- Regulation of endothelial and vascular smooth muscle [Ca2+]i
Teaching
advisees
-
graduate advising relationship
- Ahmadian, Rosstin, Ph.D. candidate, 2018 -
- Yan, Simin, Ph.D. candidate, 2017 -
- Maston, Levi, Ph.D. candidate, - 2017
- Zhang, Bojun, Ph.D. candidate, - 2017
- Sheak, Joshua, Ph.D. candidate, - 2017
- Norton, Charles, Ph.D. candidate, - 2015
- Menicucci, Steven, M.Sc. candidate, - 2011
- Snow, Jessica, Ph.D. candidate, - 2009
- Resta, Thomas advising Jernigan, Nikki - 2004
- Jernigan, Nikki, Ph.D. candidate, - 2004
- Mukundan, Harshini, Ph.D. candidate, - 2003
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postdoc or fellow advising relationship
- Weise Cross, Laura, 2015 -
- Snow, Jessica, 2009 - 2014
- Michelle, Sands, 2011 - 2012
- Jernigan, Nikki, 2006 - 2008
- Broughton, Brad, 2005 - 2007
- Kitzis, Vanessa, 2003 - 2005
- Mukundan, Harshini, 2003
Service
professional service activities
- American Physiological Society Respiration Section Awards Committee 2018 -
- NIH/NHLBI, Division of Cardiovascular Sciences Member, Advisory Board, Diversity Training Programs 2018 -
- American Physiological Society Editor, Comprehensive Physiology, Respiration Section: Pulmonary Circulation/Non-Respiratory Functions 2017 -
- NIH/NHLBI Member, Review Panel for T32 Training Grants 2016 -
- American Physiological Society Member, Editorial Board, Am. J. Physiol. Heart Circ. Physiol. 2011 -
- Pulmonary Vascular Research Institute Member, Editorial Board, Pulmonary Circulation 2010 -
- American Physiological Society Member, Editorial Board, Am. J. Physiol. Lung Cell. Mol. Physiol. 2004 -
- NIH/NHLBI Adhoc Member, Respiratory Integrative Biology and Translational Research (RIBT) Study Section 2004 -
- American Heart Association Member, National Portfolio Management Subcommittee Comission 2016 - 2018
- American Heart Association Chairman, Southwest Affiliate Research Committee 2013 - 2014
- American Heart Association Member, American Heart Association Southwest Affiliate Board of Directors 2013 - 2014
- American Heart Association Regular Member, American Heart Association, Lung Respiration and Resuscitation, National Peer Review Committee 2012 - 2014
- American Physiological Society Member, Committee on Committees 2010 - 2014
- American Physiological Society Member, Respiration Section Steering Committee 2008 - 2014
- American Physiological Society Member, Respiration Section Program Committee 2008 - 2012
- American Physiological Society Chairman, Respiration Section Nominations Committee 2008 - 2010
- American Heart Association Member, South Central Affiliate Research Committee 2007 - 2010
- American Heart Association Regular Member, Lung Resuscitation and Respiration National Peer Review Committee 2007 - 2008
- American Thoracic Society Editor, Pulmonary Circulation Assembly On-Line Journal Club, Pulmonary Hypertension/Vascular Remodeling Section 2004 - 2007
Background
education and training
- Ph.D. in Physiology, UNM School of Medicine 1995
- B.S. in Biology, UNM 1990
- Postdoctoral Fellow , UNM School of Medicine 1995 - 1998
awards and honors
- Fellow of the American Physiological Society, 2019
- Hippo Award - Best Lecturer, MD Class of 2021, 2019
- Fellow of the American Heart Association, 2013
- Fellow of the Pulmonary Vascular Research Institute, 2010
- American Physiological Society Respiration Section New Investigator Award, 2005
- Dean’s Award of Distinction in Recognition of Outstanding Faculty Performance, conferred by UNM School of Medicine, 2000
- Sidney Solomon Memorial Award for Excellence in Integrative Physiology, conferred by UNM School of Medicine, 1998
- William G. Dail Endowed Professorship, conferred by Dept. of Neurosciences , 2017 - 2020
- Educational Excellence Award for Faculty, conferred by Phase I Medical Curriculum, 2014 - 2015
- Educational Excellence Award for Faculty, conferred by Phase I Medical Curriculum, 2010 - 2011
- Educational Excellence Award for Faculty, conferred by Biomedical Sciences Graduate Program, 2004 - 2005
- Parker B. Francis Fellowship in Pulmonary Research, conferred by Harvard School of Public Health, Boston, MA, 2000 - 2003
Contact
full name
- Tom C Resta