has collaborator Gonzalez Bosc, Laura V Associate Professor Kanagy, Nancy Professor and Department Chair
selected publications academic article Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 314:H1011-H1021. 2018 Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels.. Pflugers Archiv : European journal of physiology. 470:633-648. 2018 Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca2+ entry.. American journal of physiology. Heart and circulatory physiology. 314:H359-H369. 2018 Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network.. Anesthesiology. 129:721-732. 2018 Cholesterol Regulation of Pulmonary Endothelial Calcium Homeostasis.. Current topics in membranes. 82:53-91. 2018 Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. 2018 Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 313:H828-H838. 2017 Reduced membrane cholesterol limits pulmonary endothelial Ca(2+) entry after chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 312:H1176-H1184. 2017 Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection.. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 49:88-96. 2017 Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels.. American journal of physiology. Heart and circulatory physiology. 311:H1437-H1444. 2016 Intermittent Hypoxia in Rats Reduces Activation of Ca2+ Sparks in Mesenteric Arteries.. American journal of physiology. Heart and circulatory physiology. :-. 2015 Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle.. American journal of physiology. Lung cellular and molecular physiology. 307:L419-L430. 2014 Endothelin-1-induced vasoconstriction does not require intracellular Ca²⁺ waves in arteries from rats exposed to intermittent hypoxia.. American journal of physiology. Heart and circulatory physiology. 306:H667-H673. 2014 Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.. American journal of physiology. Heart and circulatory physiology. 306:H41-H52. 2014 Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca²⁺-activated K⁺ channels and smooth muscle Ca²⁺ sparks.. American journal of physiology. Heart and circulatory physiology. 304:H1446-H1454. 2013 Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2.. Antioxidants & redox signaling. 18:1777-1788. 2013 Phosphoinositide-dependent kinase-1 and protein kinase Cδ contribute to endothelin-1 constriction and elevated blood pressure in intermittent hypoxia.. The Journal of pharmacology and experimental therapeutics. 344:68-76. 2013 Regulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1.. American journal of physiology. Cell physiology. 303:C92-C101. 2012 Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor-dependent vasoconstriction.. American journal of physiology. Cell physiology. 302:C931-C940. 2012 Impaired myogenic tone in mesenteric arteries from overweight rats.. Nutrition & metabolism. 9:-. 2012 Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(2+)-activated potassium channels.. Circulation research. 108:1439-1447. 2011 Altered membrane lipid domains limit pulmonary endothelial calcium entry following chronic hypoxia.. American journal of physiology. Heart and circulatory physiology. 301:H1331-H1340. 2011 Increased adiposity does not exacerbate impaired vasodilation in rats exposed to eucapnic intermittent hypoxia.. Respiration; international review of thoracic diseases. 81:47-56. 2011 Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species.. Journal of applied physiology (Bethesda, Md. : 1985). 111:980-988. 2011 Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles.. Environmental health perspectives. 119:98-103. 2011 Novel role of endothelial BKCa channels in altered vasoreactivity following hypoxia.. American journal of physiology. Heart and circulatory physiology. 299:H1439-H1450. 2010 Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.. The Journal of pharmacology and experimental therapeutics. 334:753-760. 2010 Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA. 2010 Mechanisms of intermittent hypoxia induced hypertension.. Journal of cellular and molecular medicine. 14:3-17. 2010 ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry. 2009 Rat strain differences in pulmonary artery smooth muscle Ca(2+) entry following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 16:603-614. 2009 Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.. American journal of physiology. Lung cellular and molecular physiology. 295:L688-L697. 2008 Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.. American journal of physiology. Heart and circulatory physiology. 295:H434-H440. 2008 Eucapnic intermittent hypoxia augments endothelin-1 vasoconstriction in rats: role of PKCdelta.. American journal of physiology. Heart and circulatory physiology. 294:H920-H927. 2008 Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.. American journal of physiology. Lung cellular and molecular physiology. 294:L797-L806. 2008 Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity.. Journal of applied physiology (Bethesda, Md. : 1985). 104:110-118. 2008 Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 15:473-484. 2008 Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 295:L515-L529. 2008 ROK contribution to endothelin-mediated contraction in aorta and mesenteric arteries following intermittent hypoxia/hypercapnia in rats.. American journal of physiology. Heart and circulatory physiology. 293:H2911-H2918. 2007 Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats.. American journal of physiology. Lung cellular and molecular physiology. 293:L1135-L1142. 2007 Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 290:L517-L525. 2006 Role of vascular heme oxygenase in reduced myogenic reactivity following chronic hypoxia.. Microcirculation (New York, N.Y. : 1994). 13:81-88. 2006 Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension.. Hypertension. 45:705-709. 2005 Pressure-induced smooth muscle cell depolarization in pulmonary arteries from control and chronically hypoxic rats does not cause myogenic vasoconstriction. 2005 Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling.. American journal of physiology. Lung cellular and molecular physiology. 287:L1220-L1229. 2004 Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries.. American journal of physiology. Heart and circulatory physiology. 287:H2677-H2686. 2004 Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats. 2004 Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 287:L801-L808. 2004 Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 286:L947-L955. 2004 Erythropoietin administration in vivo increases vascular nitric oxide synthase expression.. Journal of cardiovascular pharmacology. 42:527-533. 2003 Pulmonary PKG-1 is upregulated following chronic hypoxia.. American journal of physiology. Lung cellular and molecular physiology. 285:L634-L642. 2003 Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.. American journal of physiology. Heart and circulatory physiology. 285:H220-H228. 2003 Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation.. American journal of physiology. Heart and circulatory physiology. 284:H838-H845. 2003 Laboratory demonstration of baroreflex control of heart rate in conscious rats.. Advances in physiology education. 26:309-316. 2002 Rate of NO scavenging alters effects of recombinant hemoglobin solutions on pulmonary vasoreactivity. 2002 48-h Hypoxic exposure results in endothelium-dependent systemic vascular smooth muscle cell hyperpolarization.. American journal of physiology. Regulatory, integrative and comparative physiology. 283:R79-R85. 2002 17beta-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta.. American journal of physiology. Lung cellular and molecular physiology. 280:L555-L564. 2001 Role of endothelin in intermittent hypoxia-induced hypertension.. Hypertension. 37:511-515. 2001 Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.. American journal of physiology. Lung cellular and molecular physiology. 280:L88-L97. 2001 Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. 1998