Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms.
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Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology.Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions.24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin.GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.