Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study. Academic Article uri icon

start page

  • 1872

end page

  • 1881

abstract

  • Gene expression profiling was performed on 97 cases of infant ALL from Children's Oncology Group Trial P9407. Statistical modeling of an outcome predictor revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. Low FLT3 expression was found in a group of infants with excellent outcome (n = 11; 5-year EFS of 100%), whereas differential expression of IRX2 and TACC2 partitioned the remaining infants into 2 groups with significantly different survivals (5-year EFS of 16% vs 64%; P < .001). When infants with MLL-AFF1 were analyzed separately, a 7-gene classifier was developed that split them into 2 distinct groups with significantly different outcomes (5-year EFS of 20% vs 65%; P < .001). In this classifier, elevated expression of NEGR1 was associated with better EFS, whereas IRX2, EPS8, and TPD52 expression were correlated with worse outcome. This classifier also predicted EFS in an independent infant ALL cohort from the Interfant-99 trial. When evaluating expression profiles as a continuous variable relative to patient age, we further identified striking differences in profiles in infants less than or equal to 90 days of age and those more than 90 days of age. These age-related patterns suggest different mechanisms of leukemogenesis and may underlie the differential outcomes historically seen in these age groups.

date/time value

  • 2012

Digital Object Identifier (DOI)

  • 10.1182/blood-2011-10-382861

PubMed Identifier

  • 22210879

volume

  • 119

number

  • 8

keywords

  • Age Factors
  • Antineoplastic Combined Chemotherapy Protocols
  • Carrier Proteins
  • Cluster Analysis
  • Cohort Studies
  • DNA-Binding Proteins
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Leukemic
  • Gene Regulatory Networks
  • Homeodomain Proteins
  • Humans
  • Infant
  • Kaplan-Meier Estimate
  • Male
  • Models, Genetic
  • Myeloid-Lymphoid Leukemia Protein
  • Nuclear Proteins
  • Oligonucleotide Array Sequence Analysis
  • Oncogene Proteins, Fusion
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prognosis
  • Transcription Factors
  • Treatment Outcome
  • Tumor Suppressor Proteins
  • fms-Like Tyrosine Kinase 3