selected publications
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academic article
- High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults. 2017
- Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.. Blood. 129:572-581. 2017
- High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL.. Leukemia. :-. 2017
- Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 129:177-187. 2017
- Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. 2016
- Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.. Nature communications. 7:-. 2016
- Characterization of leukemias with ETV6-ABL1 fusion.. Haematologica. 101:1082-1093. 2016
- Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells.. ACS nano. :-. 2016
- Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma.. Cancer. 122:1017-1028. 2016
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.. Cancer cell. 29:186-200. 2016
- Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children's Oncology Group study AALL0232.. Blood. :-. 2015
- Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.. Nature. 521:357-361. 2015
- Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia.. Molecular cancer therapeutics. 14:364-374. 2015
- A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. 2015
- Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.. Nature communications. 6:-. 2015
- Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. 2014
- SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia.. Blood. 121:148-155. 2013
- Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.. Blood. 121:485-488. 2013
- ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30:751-757. 2012
- Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.. Blood. 120:833-842. 2012
- Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.. Blood. 120:1473-1484. 2012
- Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.. Advanced healthcare materials. 1:348-353. 2012
- Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.. ACS nano. 6:2174-2188. 2012
- Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.. Blood. 119:1872-1881. 2012
- Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.. Cancer cell. 22:153-166. 2012
- Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.. Blood. 120:4197-4204. 2012
- Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.. Blood. 119:3512-3522. 2012
- Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 120:3510-3518. 2012
- Treatment-influenced associations of PML-RAR? mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia.. Blood. 120:2098-2108. 2012
- Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.. Nature genetics. 43:237-241. 2011
- Cell-specific delivery of diverse cargos by bacteriophage MS2 virus-like particles.. ACS nano. 5:5729-5745. 2011
- Drug Repurposing from an Academic Perspective.. Drug discovery today. Therapeutic strategies. 8:61-69. 2011
- Drug Repurposing from an Academic Perspective.. Drug discovery today. Therapeutic strategies. 8:61-69. 2011
- GSI-I (Z-LLNle-CHO) inhibits ?-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.. Leukemia. 25:1135-1146. 2011
- Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.. Blood. 118:3080-3087. 2011
- The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers.. Nature materials. 10:389-397. 2011
- Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.. Blood. 116:3751-3757. 2010
- Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.. Blood. 115:1394-1405. 2010
- Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.. Blood. 116:4874-4884. 2010
- Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.. Blood. 115:5312-5321. 2010
- Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.. The New England journal of medicine. 360:470-480. 2009
- Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.. JAMA. 301:393-403. 2009
- Germline genomic variants associated with childhood acute lymphoblastic leukemia.. Nature genetics. 41:1001-1005. 2009
- JAK mutations in high-risk childhood acute lymphoblastic leukemia.. Proceedings of the National Academy of Sciences of the United States of America. 106:9414-9418. 2009
- Metnase mediates chromosome decatenation in acute leukemia cells.. Blood. 114:1852-1858. 2009
- Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.. Nature genetics. 41:1243-1246. 2009
- Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129.. Pediatric blood & cancer. 53:1005-1010. 2009
- Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected].. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26:4376-4384. 2008
- Gene expression overlap affects karyotype prediction in pediatric acute lymphoblastic leukemia.. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 21:1341-1344. 2007
- A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.. Nature medicine. 12:945-949. 2006
- Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction.. Blood. 108:685-696. 2006
- Resolution of ambiguous low-level positive quantitative polymerase chain reaction results in TEL-AML1 positive ALL using a post-PCR fluorescent oligoligation method.. British journal of haematology. 135:358-361. 2006
- Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.. Leukemia. 428-430. 2014
- VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.. Leukemia. 216-220. 2014