member of
- American Association for Cancer Research Member 1997 -
- American Society of Hematology Member 1997 -
- Association for Molecular Pathology Member 1995 - 2002
- Contact Info
- Websites
Harvey, Richard C Research Professor Emeritus
Positions
- Scientific Director, Center for Molecular and Cellular Diagnostics 2010 -
- Research Professor Emeritus, Department of Pathology , School of Medicine 2010 -
- Affiliation
- Publications
- Research
- Background
- Contact
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Affiliation
Publications
selected publications
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academic article
- High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults. 2017
- Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.. Blood. 129:572-581. 2017
- High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL.. Leukemia. :-. 2017
- Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 129:177-187. 2017
- Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. 2016
- Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.. Nature communications. 7:-. 2016
- Characterization of leukemias with ETV6-ABL1 fusion.. Haematologica. 101:1082-1093. 2016
- MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: A children's oncology group study.. Leukemia. :-. 2016
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.. Cancer cell. 29:186-200. 2016
- RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.. Oncogene. :-. 2015
- Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia.. Molecular cancer therapeutics. 14:364-374. 2015
- A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. 2015
- Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.. Nature communications. 6:-. 2015
- Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. 2014
- Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.. Blood. 121:485-488. 2013
- Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.. Blood. 120:833-842. 2012
- Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.. Blood. 119:1872-1881. 2012
- Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.. Cancer cell. 22:153-166. 2012
- Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.. Blood. 119:3512-3522. 2012
- Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 120:3510-3518. 2012
- Treatment-influenced associations of PML-RAR? mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia.. Blood. 120:2098-2108. 2012
- GSI-I (Z-LLNle-CHO) inhibits ?-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.. Leukemia. 25:1135-1146. 2011
- Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.. Blood. 118:3080-3087. 2011
- Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.. Blood. 115:1394-1405. 2010
- Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.. Blood. 116:4874-4884. 2010
- Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.. Blood. 115:5312-5321. 2010
- Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.. The New England journal of medicine. 360:470-480. 2009
- JAK mutations in high-risk childhood acute lymphoblastic leukemia.. Proceedings of the National Academy of Sciences of the United States of America. 106:9414-9418. 2009
- Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.. Nature genetics. 41:1243-1246. 2009
- Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected].. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26:4376-4384. 2008
- Gene expression overlap affects karyotype prediction in pediatric acute lymphoblastic leukemia.. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 21:1341-1344. 2007
- Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction.. Blood. 108:685-696. 2006
- Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.. Leukemia. 428-430. 2014
- VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.. Leukemia. 216-220. 2014
Research
research overview
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- Leukemia and Lymphoma
- Molecular markers of disease
- Gene expression signatures in cancer
Background
education and training
- B.A., Haverford College
- Ph.D. in Genetics, University of Pennsylvania
- Ph.D. in Genetics, University of Pennsylvania 1983 - 1989
- B.A., Haverford College , Biology 1977 - 1981
- University of California, San Francisco , Department of Hematology 1989 - 1992
Contact
full name
- Richard C Harvey