Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Review uri icon

authors

start page

  • 1252

end page

  • 1265

abstract

  • Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently as a decade ago. In 2005, the NIH launched the decade-long Molecular Libraries Program with the intent of innovating in and broadening access to small-molecule science. This Perspective describes how novel small-molecule probes identified through the program are enabling the exploration of biological pathways and therapeutic hypotheses not otherwise testable. These experiences illustrate how small-molecule probes can help bridge the chasm between biological research and the development of medicines but also highlight the need to innovate the science of therapeutic discovery.Copyright © 2015 Elsevier Inc. All rights reserved.

date/time value

  • June 2015

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2015.05.023

PubMed Identifier

  • 26046436

volume

  • 161

number

  • 6