High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Academic Article uri icon

start page

  • 402

end page

  • 410

abstract

  • Ovarian cancer is the leading cause of death from gynecologic cancers in the United States. Failure may be due to variable expression and/or complex interactions of growth factor receptors in individual tumors. As ErbB3-MET cooperativity is implicated in solid tumor resistance to EGFR/ErbB2 inhibitors, we evaluated expression of MET and all 4 ErbB family members in ovarian cancers. Tissue arrays were prepared from archival formalin-fixed paraffin-embedded tumor samples, including 202 ovarian carcinomas (Stage I-IV) and controls. Of 202 patient samples, only 25% were positive for EGFR and 35% for ErbB2 expression. ErbB3, ErbB4, and MET showed marked expression in 76%, 98%, and 96% of cases. Consistent with high incidence, there was no significant correlation for expression of ErbB3, ErbB4, or MET with outcome. On the basis of their high expression in the majority of cases, inhibitors targeting ErbB3, ErbB4, and/or MET may be broadly applicable as therapeutic agents in this disease.

date/time value

  • July 2014

Digital Object Identifier (DOI)

  • 10.1097/PGP.0000000000000081

PubMed Identifier

  • 24901400

volume

  • 33

number

  • 4

keywords

  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms
  • Prognosis
  • Proto-Oncogene Proteins c-met
  • Receptor, ErbB-3
  • Receptor, ErbB-4
  • Tissue Array Analysis
  • Tumor Markers, Biological