Publications in VIVO

Co-author Network

Wilson, Bridget S Professor

Positions

Director, NM Center for Spatiotemporal Modeling of Cell Signaling
Leader, Hematologic Malignancies Program, UNM Comprehensive Cancer Center , Department of Internal Medicine
Victor & Ruby Hansen Surface Professor, Department of Pathology , School of Medicine

The Wilson laboratory combines an interest in signal transduction and membrane organization/trafficking in the context of normal and disease cells. Funding in the laboratory comes from R01 grants awarded by NIAID and NCI, as well as an NIGMS P50 grant to support the New Mexico Spatiotemporal Modeling Center (STMC). We also acknowledge important prior funding from the Leukemia/Lymphoma Society and the American Cancer Society.

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selected publications

academic article
- Leukemia-derived exosomes and cytokines pave the way for entry into the brain.. Journal of leukocyte biology. 105:741-753. 2019
- Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia.. Pediatric blood & cancer. 64:-. 2017
- Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.. Science signaling. 9:-. 2016
- Spatial modeling of drug delivery routes for treatment of disseminated ovarian cancer.. Cancer research. :-. 2015
- Orchestration of ErbB3 signaling through heterointeractions and homointeractions.. Molecular biology of the cell. 26:4109-4123. 2015
- Enhanced dimerization drives ligand-independent activity of mutant EGFR in lung cancer.. Molecular biology of the cell. :-. 2015
- Membrane-mediated regulation of the intrinsically disordered CD3ϵ cytoplasmic tail of the TCR.. Biophysical journal. 108:2481-2491. 2015
- Mpl traffics to the cell surface through conventional and unconventional routes.. Traffic (Copenhagen, Denmark). 15:961-982. 2014
- 3-Dimensional Tracking of Non-blinking 'Giant' Quantum Dots in Live Cells.. Advanced functional materials. 24:4796-4803. 2014
- High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 33:402-410. 2014
- Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.. ACS chemical biology. 9:1508-1519. 2014
- erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.. Molecular and cellular biology. 34:965-977. 2014
- Pyrosequencing for Classification of Human FcγRIIIA Allotypes: A Comparison with PCR-Based Techniques. Molecular Diagnosis & Therapy. 2014
- The architectural relationship of components controlling mast cell endocytosis.. Journal of cell science. 126:4913-4925. 2013
- Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modeling.. Biophysical journal. 105:1533-1543. 2013
- Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodies.. Leukemia. :-. 2013
- Ovarian tumor attachment, invasion, and vascularization reflect unique microenvironments in the peritoneum: insights from xenograft and mathematical models.. Frontiers in oncology. 3:-. 2013
- A novel mechanism for FceRI-mediated Stat5 tyrosine phosphorylation and the selective influence of Stat5B over mast cell cytokine production. Journal of Biological Chemistry. 287:2045-2054. 2012
- Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.. American journal of physiology. Renal physiology. 302:F865-F874. 2012
- Insights into cell membrane microdomain organization from live cell single article tracking of the IgE high affinity receptor, FceRI, of mast cells. Bulletin of Mathematical Biology. 74:1857-1911. 2012
- Mast cell synapses and exosomes: membrane contacts for information exchange.. Frontiers in immunology. 3:-. 2012
- Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.. The Journal of biological chemistry. 287:2045-2054. 2012
- Subcellular distribution of Lck during CD4 T cell maturation in the thymic medulla regulates the T cell activation threshold. Proceedings of the National Academy of Sciences. 109:7415-7420. 2012
- Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. 2012
- Using hierarchical clustering and dendrograms to quantify the clustering of membrane proteins. Bulletin of Mathematical Biology. 74:190-211. 2012
- Confocal imaging studies cast doubt on nuclear localization of JAK2V617F. Blood. 118:2633-2634. 2011
- Confocal imaging studies cast doubt on nuclear localization of JAK2V617F.. Blood. 118:2633-2634. 2011
- ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.. Nature structural & molecular biology. 18:1244-1249. 2011
- GSI-I (Z-LLNle-CHO) inhibits ?-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.. Leukemia. 25:1135-1146. 2011
- Spatio-temporal signaling in mast cells.. Advances in experimental medicine and biology. 716:91-106. 2011
- Formation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces.. Journal of immunology (Baltimore, Md. : 1950). 184:1328-1338. 2010
- IKK inhibitor bay 11-7082 induces necroptotic cell death in precursor-B acute lymphoblastic leukaemic blasts.. British journal of haematology. 148:487-490. 2010
- Reduced FcepsilonRI-mediated release of asthma-promoting cytokines and chemokines from human basophils during omalizumab therapy.. International archives of allergy and immunology. 151:275-284. 2010
- SERS nanosensors that report pH of endocytic compartments during Fc?RI transit.. Analytical and bioanalytical chemistry. 398:2019-2029. 2010
- Spatio-temporal modeling of signaling protein recruitment to EGFR.. BMC systems biology. 4:-. 2010
- Time-resolved three-dimensional molecular tracking in live cells.. Nano letters. 10:4732-4737. 2010
- Caught in the act: quantifying protein behaviour in living cells.. Trends in cell biology. 19:566-574. 2009
- Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction.. PloS one. 4:-. 2009
- Sensitivity analysis predicts that the ERK-pMEK interaction regulates ERK nuclear translocation.. IET systems biology. 3:329-341. 2009
- Small, mobile FcepsilonRI receptor aggregates are signaling competent.. Immunity. 31:469-479. 2009
- Stochastic modeling of calcium in 3D geometry.. Biophysical journal. 96:1691-1706. 2009
- A comparison of inflammatory mediators released by basophils of asthmatic and control subjects in response to high-affinity IgE receptor aggregation.. International archives of allergy and immunology. 145:182-192. 2008
- Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization.. Nature cell biology. 10:955-963. 2008
- Differential expression of Ikaros isoforms in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia.. Journal of pediatric hematology/oncology. 30:941-944. 2008
- Markov random field modeling of the spatial distribution of proteins on cell membranes.. Bulletin of mathematical biology. 70:297-321. 2008
- Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation.. IET systems biology. 2:256-272. 2008
- Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization.. Molecular biology of the cell. 18:1410-1420. 2007
- FcepsilonRI and Thy-1 domains have unique protein and lipid compositions.. Journal of lipid research. 48:1325-1335. 2007
- Mapping ErbB receptors on breast cancer cell membranes during signal transduction.. Journal of cell science. 120:2763-2773. 2007
- Characterizing the topography of membrane receptors and signaling molecules from spatial patterns obtained using nanometer-scale electron-dense probes and electron microscopy.. Micron (Oxford, England : 1993). 37:14-34. 2006
- Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton.. Proceedings of the National Academy of Sciences of the United States of America. 103:18992-18997. 2006
- Reaction diffusion modeling of calcium dynamics with realistic ER geometry.. Biophysical journal. 91:537-557. 2006
- Revealing the topography of cellular membrane domains by combined atomic force microscopy/fluorescence imaging.. Biophysical journal. 90:2404-2413. 2006
- Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.. Journal of immunology (Baltimore, Md. : 1950). 175:7880-7888. 2005
- Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes.. Molecular biology of the cell. 15:2580-2592. 2004
- The Src kinase Lyn is a negative regulator of mast cell proliferation.. Journal of leukocyte biology. 75:143-151. 2004
- Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells.. Molecular biology of the cell. 9:483-496. 1998
- Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.. Molecular biology of the cell. 6:1145-1158. 1995
- Comparison of serum beta-2-microglobulin levels in patients with symptoms of allergic rhinitis and elevated modified RAST scores vs. a control population.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 100:1-5. 1989