I am a cell biologist with broad experience in cancer immunobiology and research interests in pediatric acute lymphoblastic leukemia (ALL). Currently, my research focuses on biology of pediatric T-cell lineage ALL (T-ALL) with an emphasis on aberrant cell signaling pathways, cell migration, CNS infiltration and phenomenon of minimal residual disease. I have been also interested in developing new biomarkers for leukemia treatment and risk-classification, and testing new leukemia drug candidates.
For the past few years I have been working on ALL projects and investigated the efficacy of novel monoclonal antibodies, immunotoxins and small inhibitors in the treatment of this disease. My publications document my extensive experience in molecular and cell biology including assessment of cell-cell interactions, gene expression profiling, modification of cell signaling pathways and in vivo xenograft models of human leukemia. I am a Member of the Children’s Oncology Group (COG) where I have the opportunity to address important biological questions related to translational research in leukemia pathobiology and clinical trials.