I am a cell biologist with broad experience in cancer immunobiology, imuunotherapy and gene expression profiling. My interests focus on biology of B and T-cell acute lymphoblastic leukemia (ALL), developing new biomarkers for leukemia treatment and risk classification, and testing new leukemia drug candidates. For the past few years I have investigated the efficacy of novel monoclonal antibodies, immunotixins and small inhibitors in the treatment of B-ALL. Currently my research focuses on the role of recurrent genomic lesions and secondary events in the development and progression of high-risk T-ALL with strong emphasis on aberrant epigenetic regulation. I am skilled in testing cell-cell interactions, cell signaling, gene expression, cytogenetics, and in vivo murine xenograft models. My mentors, Drs. Scott Ness and Stuart Winter have long-standing, NIH-funded research programs in genetics and hematopoietic malignancies. I have found their combined expertise in clinical and basic science extremely valuable and supportive for developing my career and interests in leukemia biology and translational research. As a junior faculty member in Pediatrics, my goal is to develop an independent translational research program that would broaden my expertise in ALL biology and to identify new potential programs to benefit patients who have acute leukemia.
- BIOM 515 Cancer Biology Instructor 2013 -