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Publications in VIVO

Parra, Karlett J Chair of the Department of Biochemistry and Molecular Biology


Our lab investigates the molecular mechanisms that regulate function and orchestrate assembly of V-ATPase proton pumps with emphasis on the mechanisms by which glucose metabolism and V-ATPases interplay. Our goals include: i) defining the contribution of V-ATPase-mediated pH homeostasis in health and disease; ii) identifying V-ATPase-dependent pathways and cellular events that could be used to selectively target V-ATPase pumps and control processes relevant to disease; and iii) establishing the molecular mechanisms that regulate activity and assembly of V-ATPase proton pumps. In pursue of these goals our lab uses several model systems (cancer cell lines, S. cerevisiae, C. albicans) and biochemical and genetics tools. Our research group consists of 1 Assistant Research Professor, 2 Ph.D. students, and 1 ASERT Post-doctoral Fellow. Dr. Parra has previously mentored/trained 4 Post-doctoral Fellows, 3 M.S. students, 42+ undergraduate students, and 6 high school students.