Although ignored until recently for not complying with the central dogma of molecular biology, noncoding RNAs (ncRNAs) are emerging as important novel regulators of diverge cellular processes. Understanding the function of both small and large ncRNAs has led to the recognition of their ability to fine-tune the expression of numerous protein-coding genes and orchestrate the activity of complex regulatory pathways, just like a conductor in a musical performance. The capacity of ncRNAs to engage in “molecular multitasking” positions them to link multiple genetic risk factors for polygenic human genetic disorders into functional networks. We will utilize novel methodologies to elucidate the unexplored role of ncRNAs in both prenatal brain development and postnatal neuronal integration and utilize the attained knowledge to better understand and potentially treat neuropsychiatric disorders.
