miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.
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abstract
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Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.© 2011 Nature America, Inc. All rights reserved.
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Research
keywords
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Age Factors
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Analysis of Variance
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Animals
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Animals, Newborn
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Calcium
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Critical Period (Psychology)
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Darkness
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Dendritic Spines
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Dominance, Ocular
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Excitatory Postsynaptic Potentials
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Gene Expression Profiling
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Gene Expression Regulation, Developmental
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In Vitro Techniques
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Luminescent Proteins
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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MicroRNAs
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Molecular Sequence Data
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Nerve Tissue Proteins
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Neuronal Plasticity
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Oligonucleotide Array Sequence Analysis
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Patch-Clamp Techniques
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Photic Stimulation
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Pyramidal Cells
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Sensory Deprivation
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Signal Transduction
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Visual Cortex
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