member of American Association for the Advancement of Science Member 2010 - American Society for Cell Biology Member 2010 - Biophysical Society Member 1998 -
has collaborator Cannon, Judy Associate Professor Ozbun, Michelle A Professor, The Maralyn S. Budke Endowed Professor of Viral Oncology Steinkamp, Mara Assistant ProfessorFaculty Director, UNM CCC Animal Models Shared Resource Ward, Heather H Assistant Professor
selected publications academic article Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.. Science signaling. 9:-. 2016 Orchestration of ErbB3 signaling through heterointeractions and homointeractions.. Molecular biology of the cell. 26:4109-4123. 2015 Enhanced dimerization drives ligand-independent activity of mutant EGFR in lung cancer.. Molecular biology of the cell. :-. 2015 Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.. The Journal of cell biology. :-. 2015 Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM.. Biophysical journal. 108:1013-1026. 2015 Resolution improvement by 3D particle averaging in localization microscopy.. Methods and applications in fluorescence. 3:-. 2015 Fluorogen-activating proteins provide tunable labeling densities for tracking FcεRI independent of IgE.. ACS chemical biology. 10:539-546. 2015 Bcl-2 together with PI3K p110α regulates cell morphology and cell migration.. Cell death & disease. 6:-. 2015 Sequential superresolution imaging of multiple targets using a single fluorophore. 2015 3-Dimensional Tracking of Non-blinking 'Giant' Quantum Dots in Live Cells.. Advanced functional materials. 24:4796-4803. 2014 Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.. ACS chemical biology. 9:1508-1519. 2014 erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.. Molecular and cellular biology. 34:965-977. 2014 The spatiotemporal organization of ErbB receptors: insights from microscopy.. Cold Spring Harbor perspectives in biology. 6:-. 2014 The architectural relationship of components controlling mast cell endocytosis.. Journal of cell science. 126:4913-4925. 2013 Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modeling.. Biophysical journal. 105:1533-1543. 2013 Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope. 2013 Advances in high-resolution imaging--techniques for three-dimensional imaging of cellular structures.. Journal of cell science. 125:2571-2580. 2012 Insights into cell membrane microdomain organization from live cell single article tracking of the IgE high affinity receptor, FceRI, of mast cells. Bulletin of Mathematical Biology. 74:1857-1911. 2012 Mast cell synapses and exosomes: membrane contacts for information exchange.. Frontiers in immunology. 3:-. 2012 Single-particle tracking of immunoglobulin E receptors (Fc?RI) in micron-sized clusters and receptor patches.. FEBS letters. 586:416-421. 2012 ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.. Nature structural & molecular biology. 18:1244-1249. 2011 Interleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitment. 2011 Spatio-temporal signaling in mast cells.. Advances in experimental medicine and biology. 716:91-106. 2011 ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.. The Journal of biological chemistry. 285:3092-3102. 2010 Formation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces.. Journal of immunology (Baltimore, Md. : 1950). 184:1328-1338. 2010 Time-resolved three-dimensional molecular tracking in live cells.. Nano letters. 10:4732-4737. 2010 Caught in the act: quantifying protein behaviour in living cells.. Trends in cell biology. 19:566-574. 2009 Sensitivity analysis predicts that the ERK-pMEK interaction regulates ERK nuclear translocation.. IET systems biology. 3:329-341. 2009 Small, mobile FcepsilonRI receptor aggregates are signaling competent.. Immunity. 31:469-479. 2009 Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization.. Nature cell biology. 10:955-963. 2008 Virus activated filopodia promote human papillomavirus type 31 uptake from the extracellular matrix.. Virology. 381:16-21. 2008 Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization.. Molecular biology of the cell. 18:1410-1420. 2007 Mapping ErbB receptors on breast cancer cell membranes during signal transduction.. Journal of cell science. 120:2763-2773. 2007 Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors.. The Journal of cell biology. 170:619-626. 2005 Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction.. Nature biotechnology. 22:198-203. 2004
education and training B.S. in Physics, Nebraska Wesleyan University Ph.D., University of Minnesota Ph.D. in Biophysical Sciences and Medical Physics, University of Minnesota 2002 B.S. in Physics, Nebraska Wesleyan University 1994 Max Planck Institute for Biophysical Chemistry, Groettingen, Germany , Department of Molecular Biology 2002 - 2005