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Perkins, Douglas Professor

Positions

Professor, Department of Internal Medicine
Director, Center for Global Health

Dr. Perkins is a Professor of Medicine and Director of the Center for Global Health in the Department of Internal Medicine. Dr. Perkins received his Ph.D. from Ohio State University (1997) and did postdoctoral training in hematology at Duke University (1997-2000). In addition, he did further training in the Malaria Molecular Vaccine Section at the Centers for Disease Control and Prevention (2000-2001). Research projects in Dr. Perkins' laboratories are based primarily in the US and Kenya. These projects focus on various molecular aspects of the human host-immune response to parasites and viruses. One primary goal of the laboratories is to determine the role of genetic variation in cytokine, chemokine, and effector molecule genes in conditioning susceptibility to Plasmodium falciparum-induced severe malarial anemia in African children. The laboratories are also actively investigating the molecular basis of enhanced immune dysfunction in individuals co-infected with human immunodeficiency virus (HIV) and malaria. Additional projects are focused on the impact of bacteremia on the morbidity and mortality of pediatric populations residing in holoendemic P. falciparum transmission areas. Research projects in Dr. Perkins' laboratories involve active collaborations with the Centers for Disease Control and Prevention, Kenya Medial Research Institute (Kisumu, Kenya), Ministry of Health, Kenya (MOH, Kenya), Kenyatta University ( Nairobi, Kenya), Maseno University (Maseno, Kenya), Mahidol University, Hospital for Tropical Disease Research (Bangkok, Thailand), Universidad de Valle (Cali, Colombia), and University of Georgia.

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selected publications

academic article
- Diabetes mellitus risk for 102 drugs and drug combinations used in patients with bipolar disorder.. Psychoneuroendocrinology. 112:-. 2020
- Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region.. Journal of human genetics. :-. 2019
- Imputation and characterization of uncoded self-harm in major mental illness using machine learning. 2019
- Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum.. BMC medical genetics. 20:-. 2019
- Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children.. EBioMedicine. 45:290-302. 2019
- Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling.. EBioMedicine. 45:278-289. 2019
- Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.. Journal of affective disorders. 252:201-211. 2019
- Preferences of Information Dissemination on Treatment for Bipolar Disorder: Patient-Centered Focus Group Study.. JMIR mental health. 6:-. 2019
- Comprehensive comparison of monotherapies for psychiatric hospitalization risk in bipolar disorders. . Bipolar disorders. 2018
- Systemic challenges in bipolar disorder management: A patient-centered approach.. Bipolar disorders. 19:676-688. 2017
- Systemic challenges in bipolar disorder management: A patient-centered approach.. Bipolar disorders. 19:676-688. 2017
- Antimalarials: Molecular Drug Targets And Mechanism of Action.. Current topics in medicinal chemistry. :-. 2017
- Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.. Molecular medicine (Cambridge, Mass.). :-. 2016
- Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort.. Bipolar disorders. 18:247-260. 2016
- Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12:773-779. 2013
- Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.. Biochemical and biophysical research communications. 436:585-590. 2013
- Feedback-based, system-level properties of vertebrate-microbial interactions. 2013
- Connecting network properties of rapidly disseminating epizoonotics. 2012
- Functional haplotypes of Fc gamma (Fc?) receptor (Fc?RIIA and Fc?RIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.. Human genetics. 131:289-299. 2012
- Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands.. BMC infectious diseases. 12:-. 2012
- Reduced interferon (IFN)-? conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.. Human genetics. 131:1375-1391. 2012
- Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.. American journal of hematology. 87:782-789. 2012
- Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.. American journal of hematology. 87:652-658. 2012
- Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.. Infection and immunity. 79:4923-4932. 2011
- Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.. Infection and immunity. 79:4674-4680. 2011
- Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.. American journal of hematology. 86:155-162. 2011
- Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by H?D2 gene expression and IL-8 release.. PloS one. 6:-. 2011
- Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.. BMC genetics. 12:-. 2011
- Severe malarial anemia: innate immunity and pathogenesis.. International journal of biological sciences. 7:1427-1442. 2011
- A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.. Infection and immunity. 78:453-460. 2010
- Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.. British journal of haematology. 149:711-721. 2010
- Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1.. American journal of hematology. 85:227-233. 2010
- Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.. Human genetics. 124:515-524. 2008
- Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.. Clinical immunology (Orlando, Fla.). 126:211-221. 2008
- Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.. The Journal of infectious diseases. 198:1219-1226. 2008
- Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria.. The American journal of tropical medicine and hygiene. 76:1033-1036. 2007
- Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.. Infection and immunity. 75:201-210. 2007
- Olanzapine and haloperidol in first episode psychosis: two-year data.. Schizophrenia research. 86:234-243. 2006
- Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.. Infection and immunity. 74:5249-5260. 2006
- Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.. The American journal of tropical medicine and hygiene. 74:573-577. 2006
- Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria.. Clinical immunology (Orlando, Fla.). 119:219-225. 2006
- Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.. AIDS (London, England). 20:275-280. 2006
- Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.. The American journal of tropical medicine and hygiene. 74:376-385. 2006
- Suppression of RANTES in children with Plasmodium falciparum malaria.. Haematologica. 91:1396-1399. 2006
- Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.. The Journal of infectious diseases. 193:1384-1393. 2006
- Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria.. Infection and immunity. 73:4190-4197. 2005
- Impaired systemic production of prostaglandin E2 in children with cerebral malaria.. The Journal of infectious diseases. 191:1548-1557. 2005
- Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-alpha regulation and viral replication.. AIDS (London, England). 19:1771-1780. 2005
- Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.. Infection and immunity. 72:4868-4873. 2004
- Hemozoin differentially regulates proinflammatory cytokine production in human immunodeficiency virus-seropositive and -seronegative women with placental malaria.. Infection and immunity. 72:7022-7029. 2004
- The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. I. Study rationale and design.. Schizophrenia research. 61:7-18. 2003
- The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. II. Baseline characteristics of the "prodromal" sample.. Schizophrenia research. 61:19-30. 2003
- In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10.. Biochemical and biophysical research communications. 311:839-846. 2003
- Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.. The Journal of infectious diseases. 185:127-131. 2002
- MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.. The Journal of infectious diseases. 200:629-637.
- Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.. Microbes and infection / Institut Pasteur. 11:811-819.
- Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.. Molecular medicine (Cambridge, Mass.). 10:45-54.
- Suppression of a novel hematopoietic mediator in children with severe malarial anemia.. Infection and immunity. 77:3864-3871.