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Hartley, Rebecca Professor

Positions

Rebecca S. Hartley, Ph.D. is a Professor of Cell Biology and Physiology, Executive Director of Program Evaluation, Education, and Research and an Associate Member of the UNM Cancer Center at the University of New Mexico School of Medicine. She earned her BS in Biology from the University of New Mexico, and her Ph.D. in Biological Structure from the University of Washington in 1992, and completed her postdoctoral studies at the University of Colorado Health Sciences Center and the University of Rennes, France. During this time she began studies on developmental regulation of the embryonic cell cycle, focusing first on post-translational and then post-transcriptional regulatory mechanisms. In 1998, she joined the faculty at the University of Iowa where her group described zygote-mediated deadenylation of maternal cyclin mRNAs as a key mechanism of embryonic cell cycle remodeling. She continued these studies after her move back home to New Mexico; collaborating with Professors James Dahlberg and Elsebet Lund to show that a zygote transcribed microRNA mediates maternal cyclin deadenylation. Her studies of the Xenopus laevis embryonic cell cycle led directly to her current studies on post-transcriptional regulation of the breast cancer cell cycle.

Prof. Hartley’s work has shown that the RNA binding proteins and microRNAs that regulate maternal cyclins are deregulated in breast cancer cells, leading to cyclin overexpression and cell cycle disruption. Her current studies focus on a stress-induced RNA binding protein that suppresses breast cancer growth by modulating the inflammatory environment. She also has collaborative medical education research projects focused on anatomy learning and student academic success.

Research Areas research areas

selected publications