The Human MR Imaging Research Lab develops novel diagnostic MRI methods for characterizing human brain function and physiology. The ultimate goal is to improve individualized treatment strategies and prognosis based upon patient specific functional brain mapping. Dr. Posse pioneered real-time functional MRI and high-speed MR spectroscopic imaging, which is known as Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI).

LAB MEMBERS

Staff

• Kishore Vakamudi, MS, Research Scientist I

Postdoctoral Fellows

• N.N., PhD

Graduate Students

• Purnesh Anugolu, MS (Computer Science)
• Khaled Talaat (Nuclear Engineering)
• Matheen Basha Shaik, MS (Electrical and Computer Engineering)

Undergraduate Students

• Bruno Sa de La Roque Guimaraes (Physics)

Visiting Scientists

Current Studies

• Presurgical Mapping in Patients with Brain Tumors The objective of this study is to develop novel approaches for presurgical mapping of eloquent cortex, tumor metabolism and fiber tracts in patients with brain tumors using real-time resting-state fMRI, real-time task-based fMRI, and proton-echo-planar-spectroscopic-imaging (PEPSI).
• Concurrent High-Speed fMRI and Diffusion Tensor MRSI The objective of this study is to enable simultaneous acquisition of diffusion tensor spectroscopic imaging and high-speed functional MRI to reduce long scan times in multi-modal presurgical mapping, and validate this approach in healthy adults and in patients with brain tumors
• High frequency resting state connectivity in high-speed fMRI The objective of this study is to characterize the biophysical basis and the clinical potential of high frequency connectivity
• High-speed fMRI of resting state connectivity The objective of this study is to develop ultra-high-speed real-time fMRI by integrating simultaneous multi-slice (SMS) EPI and multi-slab echo-volumar imaging (EVI).
• Monitoring Neoadjuvant Chemotherapy Response in Breast Cancer using High-Speed 3D MR Spectroscopic Imaging of total Choline In this study, we will assess whether changes in total choline concentration [tCho] during neoadjuvant chemotherapy (NAC) are predictive of pathologic complete response (pCR) in patients with early stage breast cancer (ESBC) appropriate for NAC, and compare our findings with dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).
• MIND Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)

Current Other Projects

• Compensation of susceptibility related line broadening in MR spectroscopic imaging
• Hyperpolarized MRI
• Concurrent fMRI and EEG in patients with Epilepsy
• Mapping of cerebrovascular pulsatility and reactivity in neurological disease

PubMed search string: Posse S NOT (Posse S AND 1976[All Fields]) NOT (Posse S AND Pflege Z)
12 Patents, 2 patent applications pending

PARTNER SITES

• Mind Research Network: https://www.mrn.org/
• Center for Magnetic Resonance Research: https://www.cmrr.umn.edu/
• University of Washington - Radiology: https://rad.washington.edu/
• University of Copenhagen - Righospitalet: https://nru.dk/
• Danish Technical University: https://www.dtu.dk/
• UCLA - Radiology: http://www.bmap.ucla.edu/

Advanced Topic: Magnetic Resonance Imaging and Spectroscopy

FALL 2019

COURSE NUMBERS:

PHYC 480-006 - ECE495-003 – CS491-008 – CBE499-005 - NE499-004

PHYC 581-006 - ECE595-002 – CS591-010 – BME598-004 – NE515-007

COURSE CREDITS

3

COURSE DESCRIPTION

• This interdisciplinary undergraduate and graduate course introduces the physics and engineering aspects of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) and provides an overview of MR research in laboratories at UNM, MRN, ABQMR and Los Alamos.
• The course is cross-listed in the Departments of Physics and Astronomy, Electrical and Computer Engineering, Computer Science, Biomedical Engineering and Nuclear Engineering. It is also open to students and postdoctoral researchers in Mathematics and Statistics, Chemistry, Medical Physics and related fields, and interested students in the School of Medicine.

Department of Neurology - MSC 10 5620

1 University of New Mexico

Albuquerque, NM  87131-0001

USA