Computational and Practical Aspects of Drug Repositioning. Academic Article Review uri icon

start page

  • 299

end page

  • 306

abstract

  • The concept of the hypothesis-driven or observational-based expansion of the therapeutic application of drugs is very seductive. This is due to a number of factors, such as lower cost of development, higher probability of success, near-term clinical potential, patient and societal benefit, and also the ability to apply the approach to rare, orphan, and underresearched diseases. Another highly attractive aspect is that the "barrier to entry" is low, at least in comparison to a full drug discovery operation. The availability of high-performance computing, and databases of various forms have also enhanced the ability to pose reasonable and testable hypotheses for drug repurposing, rescue, and repositioning. In this article we discuss several factors that are currently underdeveloped, or could benefit from clearer definition in articles presenting such work. We propose a classification scheme-drug repositioning evidence level (DREL)-for all drug repositioning projects, according to the level of scientific evidence. DREL ranges from zero, which refers to predictions that lack any experimental support, to four, which refers to drugs approved for the new indication. We also present a set of simple concepts that can allow rapid and effective filtering of hypotheses, leading to a focus on those that are most likely to lead to practical safe applications of an existing drug. Some promising repurposing leads for malaria (DREL-1) and amoebic dysentery (DREL-2) are discussed.

date/time value

  • August 2015

Digital Object Identifier (DOI)

  • 10.1089/adt.2015.29011.tiodrrr

PubMed Identifier

  • 26241209

volume

  • 13

number

  • 6

keywords

  • Animals
  • Antimalarials
  • Computational Biology
  • Drug Approval
  • Drug Evaluation, Preclinical
  • Drug Repositioning
  • Drug Therapy
  • Dysentery, Amebic
  • Humans