Filovirus vaccines. Academic Article Review uri icon

start page

  • 701

end page

  • 711

abstract

  • Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed.

date/time value

  • 2011

PubMed Identifier

  • 21519188

volume

  • 7

number

  • 6

keywords

  • Adenoviridae
  • Animals
  • Antibodies, Viral
  • Clinical Trials as Topic
  • Filoviridae
  • Filoviridae Infections
  • Genetic Vectors
  • Humans
  • Vaccination
  • Vaccines, DNA
  • Viral Vaccines
  • Virion