abstract
- Our previous study has shown that the postsynaptic dorsal column pathway is involved in transmission of pancreatic nociceptive information from the spinal cord to the thalamus. The aim of the present study was to characterize the neuronal responses in the dorsal column nuclei of the rat to pancreatic nociceptive stimulation. Brief application of bradykinin (10 microg/ml, 20s) to the surface of the pancreas resulted in a significantly increased firing rate in approximately 10% of neurons recorded. In conclusion, pancreatic nociceptive information relayed to the dorsal column nuclei is transmitted from the spinal cord through the dorsal columns.