Antibacterial activity of pepducins, allosterical modulators of formyl Peptide receptor signaling. Academic Article uri icon

start page

  • 2985

end page

  • 2988

abstract

  • Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.

date/time value

  • 2013

Digital Object Identifier (DOI)

  • 10.1128/AAC.02716-13

PubMed Identifier

  • 24590483

volume

  • 58

number

  • 5