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A lysosomal proton pump turns on when glucose runs out.
An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.
Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex.
Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease.
Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells.
Regulation of V-ATPase Reassembly by the Glycolysis Flow in PFK-1 Deficient Yeast Cells.
Zn2+-dependent activation of the Trk signaling pathway induces phosphorylation of the brain-enriched tyrosine phosphatase STEP: molecular basis for Zn2+-induced ERK MAPK activation.
Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD.
Selective Sensitization of Zinc Finger Protein Oxidation by ROS Through Arsenic Binding.
Endoplasmic Reticulum (ER) Localization Is Critical for DsbA-L Protein to Suppress ER Stress and Adiponectin Down-regulation in Adipocytes.
Autophagy enhancement of intestinal epithelial tight junction barrier function by targeting claudin-2 degradation.
Receptor Tyrosine Kinase EphA5 is a Functional Molecular Target in Human Lung Cancer.
Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity.
Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.
The role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination.
Yeast Phosphofructokinase-1 Subunit Pfk2p Is Necessary for pH Homeostasis and Glucose-dependent Vacuolar ATPase Reassembly.
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.
Deletion of vacuolar proton-translocating ATPase V(o)a isoforms clarifies the role of vacuolar pH as a determinant of virulence-associated traits in Candida albicans.
Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy.
Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells.
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.
High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines.
Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.
Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer.
Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.
Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase.
Alpha4beta1 integrin affinity changes govern cell adhesion.
The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolism.
N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity.
Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus.
Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases.
Overproduction and rapid purification of the biotin operon repressor from Escherichia coli.