Onset-age of bipolar disorders at six international sites. Academic Article uri icon

start page

  • 143

end page

  • 146

abstract

  • Onset-age is a stable characteristic of bipolar disorder (BPD) patients of clinical and probable psychobiological importance, but large pooled clinical samples from multiple sites employing modern diagnostic criteria to quantify onset-age remain rare.We pooled diagnostic, demographic, and clinical data from 1566 BPD patients from six international sites (5 European, 1 US) to compare onset-ages in subgroups.Median+/-IQR onset in 1090 BP-I patients was 5.8 years younger than 476 BP-II cases (24.3+/-18.3 vs. 30.1+/-13.8 years; p<0.0001). Onset-age ranked: [a] BP-I men (23.0+/-12.8); [b] BP-I women (26.0+/-14.2); [c] BP-II men (29.7+/-19.1); and [d] BP-II women (30.1+/-17.5 years. Juvenile-onset (

date/time value

  • February 2010

Digital Object Identifier (DOI)

  • 10.1016/j.jad.2009.05.030

PubMed Identifier

  • 19560827

volume

  • 121

number

  • 1-2

keywords

  • Adolescent
  • Adult
  • Age of Onset
  • Bipolar Disorder
  • Child
  • Cross-Cultural Comparison
  • Cross-Sectional Studies
  • Depressive Disorder, Major
  • Europe
  • Female
  • Humans
  • Male
  • Middle Aged
  • United States
  • Young Adult