has collaborator
- Castillo, Eliseo F Associate Professor
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Campen, Matthew Regents' Professor
Positions
- Professor, College of Pharmacy , Health Sciences Center
Campen received a BS in biochemistry from Virginia Tech in 1994 and a Master of Science in Public Health concentrating on environmental health from the University of North Carolina at Chapel Hill, in 1997. He received his PhD, in environmental health from UNC Chapel Hill in 2000 followed by a postdoctoral fellowship at the Johns Hopkins University School of Medicine. Prior to his current appointment, he worked as an independent scientist at the Lovelace Respiratory Research Institute in Albuquerque.
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Affiliation
Publications
selected publications
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academic article
- In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice. Environmental health perspectives. doi: 10.1289/EHP13435. 2024
- Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice. J. Neuroinflammation. doi: 10.1186/s12974-023-02874-y. 2023
- Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity.. Environmental science & technology. 55:9949-9957. 2021
- Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation and a Hyperexcited State.. Toxicological sciences : an official journal of the Society of Toxicology. :-. 2021
- Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux.. Journal of the American Society of Nephrology : JASN. :-. 2021
- Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size.. Acta biomaterialia. 114:285-295. 2020
- Autophagy, Inflammation, and Metabolism (AIM) Center in its second year.. Autophagy. :1-5. 2019
- GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin.. Scientific reports. 9:-. 2019
- Metal-Induced Pulmonary Fibrosis.. Current environmental health reports. 5:486-498. 2018
- Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood-brain barrier impairment. 2017
- Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites.. Scientific reports. 7:-. 2017
- Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.. Journal of exposure science & environmental epidemiology. :-. 2017
- Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes.. Particle and fibre toxicology. 13:-. 2016
- Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells.. Atherosclerosis. 254:59-66. 2016
- Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure.. Toxicology and applied pharmacology. 305:40-45. 2016
- Microglial priming through the lung-brain axis: the role of air pollution-induced circulating factors.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. :-. 2016
- Associations of Circulating Oxidized LDL and Conventional Biomarkers of Cardiovascular Disease in a Cross-Sectional Study of the Navajo Population. 2016
- MMP-9-Dependent Serum-Borne Bioactivity Caused by Multi-walled Carbon Nanotube Exposure Induces Vascular Dysfunction Via the CD36 Scavenger Receptor.. Toxicological sciences : an official journal of the Society of Toxicology. :-. 2016
- Ozone Inhalation Impairs Coronary Artery Dilation via Intracellular Oxidative Stress: Evidence for Serum-Borne Factors as Drivers of Systemic Toxicity.. Toxicological sciences : an official journal of the Society of Toxicology. :-. 2015
- Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures.. Cardiovascular toxicology. :-. 2015
- Characterization of a novel endothelial biosensor assay reveals increased cumulative serum inflammatory potential in stabilized coronary artery disease patients.. Journal of translational medicine. 13:-. 2015
- The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions.. Inhalation toxicology. 26:651-667. 2014
- Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling. 2014
- High sputum total adiponectin is associated with low odds for asthma. 2014
- Effects of nicotine on cardiovascular remodeling in a mouse model of systemic hypertension.. Cardiovascular toxicology. 13:364-369. 2013
- National Particle Component Toxicity (NPACT) initiative report on cardiovascular effects.. Research report (Health Effects Institute). :5-8. 2013
- To breathe or not to breathe: negative data on ozone and vascular function in an established research model.. Toxicological sciences : an official journal of the Society of Toxicology. 135:263-264. 2013
- CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure.. Toxicological sciences : an official journal of the Society of Toxicology. 134:304-311. 2013
- A healthier approach to clinical trials evaluating resveratrol for primary prevention of age‐related diseases in healthy populations.. Aging. 5:495-506. 2013
- Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.. International journal of cardiology. 166:246-248. 2013
- Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.. Cardiovascular toxicology. 12:226-234. 2012
- Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model.. Toxicological sciences : an official journal of the Society of Toxicology. 127:179-186. 2012
- Identification of chemical components of combustion emissions that affect pro-atherosclerotic vascular responses in mice.. Inhalation toxicology. 24:270-287. 2012
- Mechanisms linking traffic-related air pollution and atherosclerosis.. Current opinion in pulmonary medicine. 18:155-160. 2012
- Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.. Vascular pharmacology. 56:64-73. 2012
- Longitudinal in vivo SPECT/CT imaging reveals morphological changes and cardiopulmonary apoptosis in a rodent model of pulmonary arterial hypertension. 2012
- Engine-operating load influences diesel exhaust composition and cardiopulmonary and immune responses.. Environmental health perspectives. 119:1136-1141. 2011
- The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions.. American journal of respiratory and critical care medicine. 184:82-91. 2011
- Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles.. Environmental health perspectives. 119:312-318. 2011
- Formation of vascular S-nitrosothiols and plasma nitrates/nitrites following inhalation of diesel emissions.. Journal of toxicology and environmental health. Part A. 74:828-837. 2011
- Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust.. Inhalation toxicology. 23:1-10. 2011
- Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles.. Environmental health perspectives. 119:98-103. 2011
- A comparison of vascular effects from complex and individual air pollutants indicates a role for monoxide gases and volatile hydrocarbons.. Environmental health perspectives. 118:921-927. 2010
- In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.. Cardiovascular toxicology. 10:87-99. 2010
- Cardiopulmonary response to inhalation of biogenic secondary organic aerosol.. Inhalation toxicology. 22:253-265. 2010
- Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice.. Toxicology and applied pharmacology. 242:310-317. 2010
- Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions.. American journal of physiology. Regulatory, integrative and comparative physiology. 297:R640-R647. 2009
- Nitric oxide synthase: "enzyme zero" in air pollution-induced vascular toxicity.. Toxicological sciences : an official journal of the Society of Toxicology. 110:1-3. 2009
- Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways.. Arteriosclerosis, thrombosis, and vascular biology. 29:511-517. 2009
- Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats.. Toxicology and applied pharmacology. 232:440-447. 2008
- Health effects of subchronic inhalation exposure to gasoline engine exhaust.. Inhalation toxicology. 20:1125-1143. 2008
- Diesel exhaust exposure enhances venoconstriction via uncoupling of eNOS.. Toxicology and applied pharmacology. 230:346-351. 2008
- In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology.. Toxicological sciences : an official journal of the Society of Toxicology. 101:321-330. 2008
- Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures.. Journal of toxicology and environmental health. Part A. 71:1352-1362. 2008
- Development of a head-out plethysmograph system for non-human primates in an Animal Biosafety Level 3 facility.. Journal of pharmacological and toxicological methods. 55:96-102. 2007
- Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis.. Toxicological sciences : an official journal of the Society of Toxicology. 95:485-494. 2007
- Health effects of inhaled gasoline engine emissions.. Inhalation toxicology. 19 Suppl 1:107-116. 2007
- Heart rate variability in rodents: uses and caveats in toxicological studies.. Cardiovascular toxicology. 7:28-51. 2007
- Characterization of shock in a hamster model of hantavirus infection.. Virology. 356:45-49. 2006
- Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice.. Toxicological sciences : an official journal of the Society of Toxicology. 92:545-559. 2006
- Health effects of subchronic exposure to environmental levels of hardwood smoke.. Inhalation toxicology. 18:523-539. 2006
- Fresh gasoline emissions, not paved road dust, alter cardiac repolarization in ApoE-/- mice.. Cardiovascular toxicology. 6:199-210. 2006
- Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic rats.. Toxicological sciences : an official journal of the Society of Toxicology. 88:505-513. 2005
- Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL/6J mice. 2005
- Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE-/- mice.. Toxicological sciences : an official journal of the Society of Toxicology. 88:95-102. 2005
- Heart rate variability responses to hypoxic and hypercapnic exposures in different mouse strains. 2005
- Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice.. Physiological genomics. 20:15-20. 2004
- Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidine.. Cardiovascular toxicology. 4:133-153. 2004
- Cardiac and thermoregulatory responses to inhaled pollutants in healthy and compromised rodents: modulation via interaction with environmental factors.. Environmental research. 92:35-47. 2003
- Cardiovascular effects of inhaled diesel exhaust in spontaneously hypertensive rats.. Cardiovascular toxicology. 3:353-361. 2003
- Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice.. Physiological genomics. 11:227-234. 2002
- Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats.. Journal of toxicology and environmental health. Part A. 65:1615-1631. 2002
- A model of sleep-disordered breathing in the C57BL/6J mouse. 2001
- Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: a potential interaction between nickel and vanadium sulfate.. Toxicological sciences : an official journal of the Society of Toxicology. 64:243-252. 2001
- Cardiovascular and systemic responses to inhaled pollutants in rodents: effects of ozone and particulate matter.. Environmental health perspectives. 109 Suppl 4:539-546. 2001
- The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter.. Toxicology and applied pharmacology. 164:250-263. 2000
- Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension.. Journal of toxicology and environmental health. Part A. 57:543-563. 1999
- Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension.. Toxicological sciences : an official journal of the Society of Toxicology. 41:209-216. 1998
- Impact of the hypothermic response in inhalation toxicology studies.. Annals of the New York Academy of Sciences. 813:849-863. 1997
- Hantavirus cardiopulmonary syndrome.. Seminars in respiratory and critical care medicine. 28:193-200.
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article
- Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations.. Autophagy. 925-929. 2018
- Vascular endothelium as a target of diesel particulate matter-associated toxicants.. Archives of toxicology. 517-518. 2012
Research
research overview
- Campen is an expert in the cardiopulmonary health effects of air pollution, such as ozone, combustion emissions and nanomaterials. He is also broadly interested in the crosstalk of the cardiovascular and respiratory systems in health and disease, conducting basic and clinical research into the nature of comorbidities that promote cardiovascular illness. His primary research focus involves the impact of inhaled toxicants, especially common air pollutants, on vascular function and injury. He is currently the Director of the Mentored Career Development Program (KL2) in the Clinical Translational Science Center and Deputy Director of the new UNM Superfund Research Center.
Background
education and training
- Ph.D. in Environmental Health, University of North Carolina, Chapel Hill , School of Public Health 1997 - 2000
Contact
full name
- Matthew Campen