VUE LAB RESEARCH

Glial cells, which comprised of astrocytes and oligodendrocytes, are highly proliferative and constitute the majority of the cells in the central nervous system (CNS). Research in the Vue Lab aims to understand the cellular and molecular mechanisms underlying the development and heterogeneity of glial cells under normal development and in disease states and cancer.

Research Programs

• Glial Development – Mechanisms of glial cell fate specification, proliferation, migration and differentiation; heterogeneity and function of astrocytes and oligodendrocytes in gray matter and white matter of the CNS; affects of prenatal alcohol exposure (PAE).

• Glioma Development – Mechanisms of brain tumor formation and progression in mouse models of glioblastoma multiforme (GBM).

Publications: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/53788959/?sort=date&direction=ascending

• Kelenis, DP., Hart, E., Edwards-Fligner, M., Johnson, JE., and Vue, TY. ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord. GLIA 2018; 66(9):1862-1880. DOI: 10.1002/glia.23344. PMID: 29683222.

• Niu, W., Zang, T., Smith, DK., Vue, TY., Zou, Y., Bachoo R., Johnson JE., and Zhang, CL. SOX2 reprograms resident astrocytes into neural progenitors in the adult brain. Stem Cell Reports 2015 4(5):780-94. PMID: 25921813

• Vue, TY*., Kim, EJ., Parras, C., Guillemot, F., and Johnson, JE. Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the grey matter and white matter of the spinal cord. Development 2014 141(19):3721-31. PMID: 25249462.

• Mich, JK., Signer, RAJ., Nakada, D., Pineda, A., Burgess, RJ., Vue, TY., Johnson, JE., and Morrison, SJ. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. eLife 2014 7;3;e02669. PMID: 24843006.

• Vue, TY*., Lee, M., Tan, YE., Werkhoven, Z., Wang, L., and Nakagawa, Y. Thalamic control of neocortical area formation in mice. Journal of Neuroscience 2013 33(19):8442-8453. PMID: 23658181.

• Bluske, K., Vue, TY., Kawakami, Y., Taketo, MM., Yoshikawa Y., Johnson, JE., and Nakagawa, Y. Wnt/β-catenin signaling specifies progenitor cell identity in concert with Shh signaling in the developing mammalian thalamus. Development 2012 139(15):2692-702. PMID: 22745311.

• Vue, TY*., Bluske, K., Alishahi, A., Yang, LL., Koyano-Nakagawa, N., Novitch, B., and Nakagawa, Y. Sonic Hedgehog Signaling Controls Thalamic Progenitor Identity and Nuclei Specification in Mice. Journal of Neuroscience 2009 29(14):4484-4497.  PMID: 19357274.

• Vue, TY*., Aaker, J., Taniguchi, A., Kazemzadeh, C., Skidmore, JM., Martin, DM., Martin, JF., Treier, M., and Nakagawa, Y. Characterization of progenitor domains in the developing mouse thalamus. Journal of Comparative Neurology 2007 505: 73-91. PMID: 17729296.