selected publications academic article Translational models for vascular cognitive impairment: a review including larger species.. BMC medicine. 15:-. 2017 Rodent Models of Vascular Cognitive Impairment.. Translational stroke research. :-. 2016 Transient increase of fractional anisotropy in reversible vasogenic edema.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. :-. 2016 Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease.. Stroke; a journal of cerebral circulation. 46:2413-2418. 2015 Consensus statement for diagnosis of subcortical small vessel disease.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. :-. 2015 Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. :-. 2015 Validation of biomarkers in subcortical ischaemic vascular disease of the Binswanger type: approach to targeted treatment trials.. Journal of neurology, neurosurgery, and psychiatry. :-. 2015 Binswanger's disease: toward a diagnosis agreement and therapeutic approach.. Expert review of neurotherapeutics. 14:1203-1213. 2014 Identification of Isoxsuprine Hydrochloride as a Neuroprotectant in Ischemic Stroke through Cell-Based High-Throughput Screening. 2014 Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment.. Stroke; a journal of cerebral circulation. 45:1531-1538. 2014 Tissue oxygen is reduced in white matter of spontaneously hypertensive-stroke prone rats: a longitudinal study with electron paramagnetic resonance.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34:890-896. 2014 1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.. Journal of neurology, neurosurgery, and psychiatry. :-. 2013 Dynamic contrast-enhanced MRI evaluation of cerebral cavernous malformations.. Translational stroke research. 4:500-506. 2013 Early inhibition of MMP activity in ischemic rat brain promotes expression of tight junction proteins and angiogenesis during recovery.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 33:1104-1114. 2013 Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.. Molecular brain. 6:-. 2013 Imaging of Subacute Blood-Brain Barrier Disruption After Methadone Overdose.. Journal of neuroimaging : official journal of the American Society of Neuroimaging. :-. 2013 Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia. 2013 Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia.. Experimental neurology. 240:9-16. 2013 Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons.. Neuroscience. 220:277-290. 2012 Myelin loss associated with neuroinflammation in hypertensive rats.. Stroke; a journal of cerebral circulation. 43:1115-1122. 2012 Neurological diseases in relation to the blood-brain barrier.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 32:1139-1151. 2012 Blood-brain barrier breakdown in acute and chronic cerebrovascular disease.. Stroke; a journal of cerebral circulation. 42:3323-3328. 2011 Blood-brain barrier permeability abnormalities in vascular cognitive impairment.. Stroke; a journal of cerebral circulation. 42:2158-2163. 2011 MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. 2011 Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment.. Stroke; a journal of cerebral circulation. 42:1345-1350. 2011 Modeling of cerebellar hemorrhage.. Experimental neurology. 228:157-159. 2011 Multiple roles of metalloproteinases in neurological disorders.. Progress in molecular biology and translational science. 99:241-263. 2011 Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping.. Magnetic resonance in medicine. 65:1036-1042. 2011 Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice.. J. Neuroinflammation. 8:-. 2011 Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.. Stroke; a journal of cerebral circulation. 41:790-797. 2010 Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 30:370-380. 2010 Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia. 2010 Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. 2010 Metzincin proteases and their inhibitors: foes or friends in nervous system physiology? 2010 Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 30:56-69. 2010 Vascular cognitive impairment: introduction.. Stroke; a journal of cerebral circulation. 41:S127-S128. 2010 Application of FT-based MMSE deconvolution method for cerebral blood flow measurement in patients with leukoaraiosis.. Magnetic resonance imaging. 27:625-630. 2009 Diverse Roles of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Neurological Diseases. Neuroscience. 158:983-994. 2009 Elevation of matrix metalloproteinases 3 and 9 in cerebrospinal fluid and blood in patients with severe traumatic brain injury.. Neurosurgery. 65:702-708. 2009 Experimental models in intracerebral hemorrhage.. Handbook of clinical neurology. 92:307-324. 2009 Increased apparent diffusion coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29:308-316. 2009 Inflammation and white matter damage in vascular cognitive impairment.. Stroke; a journal of cerebral circulation. 40:S20-S23. 2009 Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.. Lancet neurology. 8:205-216. 2009 Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke. 2009 TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia.. Experimental neurology. 216:122-131. 2009 The neurovascular unit in health and disease: introduction.. Stroke; a journal of cerebral circulation. 40:S2-S3. 2009 Tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) lacks involvement in bacterial collagenase-induced intracerebral hemorrhage in mouse.. Acta neurochirurgica. Supplement. 105:89-93. 2008 Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia.. Cell death and differentiation. 15:143-151. 2008 Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat.. The Journal of pharmacology and experimental therapeutics. 323:488-498. 2007 Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 27:697-709. 2007 Vasogenic Edema Secondary to Tight Junction Disruption by Matrix Metalloproteinases in Cerebral Ischemia. Neurosurgical Fucos. 22:-. 2007 Multiple roles for MMPs and TIMPs in cerebral ischemia.. Glia. 50:329-339. 2005 Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 22:1303-1310. 2002 Magnetic resonance lipid signals in rat brain after experimental stroke correlate with neutral lipid accumulation.. Neuroscience letters. 301:87-90. 2001 Matrix metalloproteinases and tissue inhibitors of metalloproteinases in cerebrospinal fluid differ in multiple sclerosis and Devic's neuromyelitis optica.. Brain : a journal of neurology. 124:493-498. 2001 Matrix metalloproteinases as therapeutic targets for stroke.. -. 2015