abstract

• The development of anti-factor VIII (FVIII) antibodies (inhibitors) is the most serious treatment-related complication in patients with hemophilia A, rendering standard replacement therapy ineffective, heightening the risk for uncontrollable bleeding and morbidity, decreasing quality of life, and increasing healthcare costs.Formulate evidence-based guidelines for optimizing immune tolerance induction (ITI) in patients with hemophilia A and inhibitors.Results from the International ITI study and other available evidence were used to develop guidelines for ITI.Predictors of ITI success were identified and recommendations made for ITI with regard to candidates, timing, product, regimen, monitoring, defining success, concurrent immunomodulation, duration of treatment, and bleed management before and during ITI.Evidence-based recommendations to guide treatment decisions may increase the likelihood of successful inhibitor eradication and the induction of FVIII tolerance in patients with hemophilia A who develop inhibitory antibodies.© 2015 John Wiley & Sons Ltd.

authors

• Valentino, L A
• Kempton, C L
• Kruse-Jarres, R
• Mathew, Prasad
• Meeks, S L
• Reiss, U M
• International Immune Tolerance Induction Study Investigators

publication date

• June 2015

published in

• Haemophilia : the official journal of the World Federation of Hemophilia  Journal

Digital Object Identifier (DOI)

• https://doi.org/10.1111/hae.12730

PubMed ID

• 26032231

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