Clinical features, causes, treatments, and outcomes of peristomal pyoderma gangrenosum (PPG) in 44 patients: The Mayo Clinic experience, 1996 through 2013.
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There are limited large case series of peristomal pyoderma gangrenosum (PPG), an uncommon cause of recalcitrant peristomal ulceration.We sought to further characterize the clinical features, causes, treatments, and outcomes of PPG.We conducted a retrospective chart review of patients with PPG seen at Mayo Clinic from January 1996 to July 2013.A total of 44 patients had PPG (mean age, 46 years; 32 women [73%]); 41 (93%) had inflammatory bowel disease. Mean time to PPG onset after stoma surgery was 5.2 months (excluding 1 outlier). Systemic therapies included corticosteroids (66%), immunosuppressants (41%), biologics (36%), and a combination of systemic treatments (36%). Mean time to reach a complete response was 10.7 weeks. Stoma closure had the greatest complete response (4 of 4 patients, no recurrences). Recurrence after any treatment was documented in 23 of 38 (61%) patients. Stoma relocation/revision recurred in 10 of 15 (67%) patients. Remission occurred in 29 of 31 (94%) patients.Small sample size and retrospective study design are limitations.PPG is strongly associated with inflammatory bowel disease, is predominant in women, and has a prolonged time to onset and high recurrence rate. Systemic corticosteroid or combination therapies and surgical closure can be effective treatments. Timely recognition and management are paramount to achieving early remission.Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
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Adolescent
Adrenal Cortex Hormones
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Biological Products
Diagnostic Errors
Disease Susceptibility
Drug Therapy, Combination
Female
Humans
Immunocompromised Host
Immunoglobulins, Intravenous
Immunosuppressive Agents
Inflammatory Bowel Diseases
Male
Middle Aged
Postoperative Complications
Pyoderma Gangrenosum
Recurrence
Reoperation
Retrospective Studies
Risk Factors
Skin Ulcer
Surgical Stomas
Young Adult
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