abstract

• Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.

authors

• Bruneau, Julie
• Cox, Andrea L
• Dore, Gregory J
• Grebely, Jason
• Hellard, Margaret
• Kim, Arthur Y
• Lauer, Georg
• Lloyd, Andrew R
• Maher, Lisa
• McGovern, Barbara H
• Mirzazadeh, A
• Morris, Meghan
• Page, Kimberly A
• Prins, Maria
• Rice, Thomas M
• Shoukry, Naglaa H

publication date

• January 2016

published in

• Open forum infectious diseases  Journal

Digital Object Identifier (DOI)

• https://doi.org/10.1093/ofid/ofw024

PubMed ID

• 26973850

start page

end page

volume

• 3

number

• 1