Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers.
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abstract
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Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.Copyright © 2013 Elsevier Ltd. All rights reserved.
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Aged
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Aged, 80 and over
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Bone Marrow
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Bone Marrow Examination
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Female
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Humans
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Janus Kinase 2
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Male
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Middle Aged
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Mutation
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Primary Myelofibrosis
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Referral and Consultation
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Retrospective Studies
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Risk Factors
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Sensitivity and Specificity
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Tertiary Care Centers
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