Effect of Octreotide on the Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation.

To study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders.This was a non-randomized, single center, open label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility RESULTS:: Thirteen patients (5 male) were enrolled in the study. The age range was 4.6-16.2 years. Eleven patients (84%) had normal colonic manometry and two patients (16%) had colonic neuropathy. Motility Index (MI) (mm Hg) for the 15 minutes before and after octreotide infusion was 6.03 ± 1.26 (95% CI, 5.35-6.72), and 5.32 ± 1.66 (95% CI, 4.42-6.23) respectively with p-value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 ± 1.37 (95% CI, 6.14-7.64) and 6.71 ± 1.47 (95% CI, 5.91-7.52) respectively with p-value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 ± 1.32 (95% CI, 7.01-8.45) and 7.53 ± 1.38 (95% CI, 6.78-8.28) respectively with p-value of 0.8.Our study showed that administration of octreotide resulted in no significant changes in colonic motility index in pediatric patients with chronic recalcitrant constipation.

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