Publications in VIVO

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Thompson, Todd Assistant Professor

The focus of research in our laboratory is cancer pharmacogenomics, evaluating the effectiveness of both prevention and treatment modalities for breast and prostate cancer. Cell culture and rodent preclinical models are used in our research to examine the effectiveness of pharmaceutical and nutritional strategies to help combat cancer. For example, the effectiveness of vitamin E as a preventive and therapeutic modality for prostate cancer is being investigated. Also, pathways of cellular differentiation are under investigation to assess their potential value in cancer prevention and treatment. Finally, studies are designed to test the effectiveness of these modalities for cancer prevention and treatment in people utilizing pharmacogenomic-based clinical analyses.

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selected publications

academic article
- Complete Genome Sequences of Four Novel Human Coronavirus OC43 Isolates Associated with Severe Acute Respiratory Infection. 2018
- Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection.. Frontiers in molecular neuroscience. 5:-. 2017
- Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based study.. Cancer medicine. 5:3336-3345. 2016
- Complete Genome Sequences of Two Novel Isolates of Human Parainfluenza Virus 1 Associated with Acute Respiratory Infection.. BMC hematology. 4:-. 2016
- Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.. BMC cancer. 16:-. 2016
- Antioxidants Abrogate Alpha-Tocopherylquinone-Mediated Down-Regulation of the Androgen Receptor in Androgen-Responsive Prostate Cancer Cells. 2016
- Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging. 2016
- A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 2015
- Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.. Atherosclerosis. 241:419-426. 2015
- Health disparities in clinical practice patterns for prostate cancer screening by geographic regions in the United States: a multilevel modeling analysis.. Prostate cancer and prostatic diseases. 16:193-203. 2013
- Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1.. Toxicology letters. 209:161-165. 2012
- The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.. The Prostate. 72:612-625. 2012
- Drug Repurposing from an Academic Perspective.. Drug discovery today. Therapeutic strategies. 8:61-69. 2011
- Drug Repurposing from an Academic Perspective.. Drug discovery today. Therapeutic strategies. 8:61-69. 2011
- Drug Repurposing from an Academic Perspective.. Drug discovery today. Therapeutic strategies. 8:61-69. 2011
- Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.. Journal of biomolecular screening. 14:596-609. 2009
- A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.. Cancer research. 69:7689-7695. 2009
- A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 73:390-399. 2008
- Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells.. Toxicology and applied pharmacology. 221:203-214. 2007
- Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells.. Molecular cancer therapeutics. 2:797-803. 2003
- Growth inhibition and differentiation in human prostate carcinoma cells induced by the vitamin D analog 1alpha,24-dihydroxyvitamin D2.. The Prostate. 55:159-167. 2003
- Decreased susceptibility to NMU-induced mammary carcinogenesis in transgenic rats carrying multiple copies of a rat ras gene driven by the rat Harvey ras promoter.. Oncogene. 21:2797-2804. 2002