Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens. Academic Article Editorial Article uri icon

abstract

  • To investigate how opioid exposure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP sensor to track cAMP dynamics and report a coordinated effort of adaptations in D1- and D2-MSNs to integrate DA inputs and shift signaling strengths in various states of opioid dependence.Copyright © 2020 Elsevier Ltd. All rights reserved.

publication date

  • December 2020