A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. Academic Article uri icon

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  • The goal of this study was to assess the effectiveness and tolerability of olanzapine in the treatment of acute mania in children and adolescents.This was an 8-week, open-label, prospective study of olanzapine monotherapy (dose range 2.5-20 mg/day) involving 23 bipolar youths (manic, mixed, or hypomanic; 5-14 years old). Weekly assessments were made using the Young Mania Rating Scale (YMRS), Clinical Global Impressions Severity Scale (CGI-S), Brief Psychiatric Rating Scale, and Children's Depression Rating Scale. Adverse events were assessed through self-reports, vital sign and weight monitoring, laboratory analytes, and extrapyramidal symptom rating scales (Barnes Akathisia Scale, Simpson-Angus Scale, and Abnormal Involuntary Movement Scale).Twenty-two of the 23 youths (96%) completed the study. Olanzapine treatment was associated with significant improvement in mean YMRS score (-19.0 +/- 9.2, p < 0.001). Using predefined criteria for improvement of > or = 30% decline in the YMRS and a CGI-S Mania score of < or = 3 at endpoint, the overall response rate was 61%. Overall, olanzapine was well tolerated, and extrapyramidal symptom measures were not significantly different from baseline. Body weight increased significantly over the study (5.0 +/- 2.3 kg, p < 0.001).Open-label olanzapine treatment was efficacious and well tolerated in the treatment of acute mania in youths with bipolar disorder. Future placebo-controlled, double-blind studies are warranted.

date/time value

  • 2001

Digital Object Identifier (DOI)

  • 10.1089/10445460152595568

PubMed Identifier

  • 11642474


  • 11


  • 3


  • Abdominal Pain
  • Adolescent
  • Antipsychotic Agents
  • Appetite
  • Benzodiazepines
  • Bipolar Disorder
  • Brief Psychiatric Rating Scale
  • Child
  • Child, Preschool
  • Disorders of Excessive Somnolence
  • Female
  • Humans
  • Male
  • Patient Compliance
  • Pirenzepine
  • Prospective Studies
  • Severity of Illness Index
  • Time Factors
  • Weight Gain