Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity. Academic Article uri icon

abstract

  • Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy in vitro and in vivo and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.Copyright © 2018 American Society for Microbiology.

publication date

  • December 2018