has collaborator
- Dell'Orco, Michela Faculty Member
- Contact Info
- 505 272 1165
Perrone-Bizzozero, Nora Professor
Positions
- Professor, Department of Neurosciences , School of Medicine
Posttranscriptional regulation of neuronal genes during brain development, nerve regeneration and synaptic plasticity. Synaptic protein regulation in schizophrenia, fetal alcohol syndrome and alcoholism. GABA and NMDA receptor dysfunction and altered myelination in schizophrenia. Neurogenomics and the genetics of schizophrenia.
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- Publications
- Research
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Affiliation
Publications
selected publications
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academic article
- Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.. Journal of cell science. 130:3650-3662. 2017
- In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens.. Molecular psychiatry. :-. 2017
- Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity.. NeuroImage. 145:96-106. 2017
- Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis.. Journal of neurochemistry. 139:640-650. 2016
- Independent component analysis of SNPs reflects polygenic risk scores for schizophrenia.. Schizophrenia research. :-. 2016
- Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum.. Alcoholism, clinical and experimental research. 40:826-837. 2016
- Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum.. Alcoholism, clinical and experimental research. 40:826-837. 2016
- A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder.. Translational psychiatry. 6:-. 2016
- Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.. Translational psychiatry. 6:-. 2016
- Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.. Wiley interdisciplinary reviews. RNA. :-. 2015
- Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function.. Biomolecules. 5:2903-2918. 2015
- Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.. Nucleic acids research. 43:7432-7446. 2015
- Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.. Nucleic acids research. 43:7432-7446. 2015
- Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. 2015
- MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.. Neuroscience letters. 602:44-49. 2015
- Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD. 2015
- GAP-43 slows down cell cycle progression via sequences in its 3'UTR.. Archives of biochemistry and biophysics. :-. 2015
- Genetic markers of white matter integrity in schizophrenia revealed by parallel ICA.. Frontiers in human neuroscience. 9:-. 2015
- Association of GRM3 polymorphism with white matter integrity in schizophrenia.. Schizophrenia research. 155:8-14. 2014
- HuD regulates coding and noncoding RNA to induce APP→Aβ processing. 2014
- Methylation patterns in whole blood correlate with symptoms in schizophrenia patients.. Schizophrenia bulletin. 40:769-776. 2014
- Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference.. NeuroImage. 83:384-396. 2013
- HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. 2013
- Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis.. ASN neuro. 5:-. 2013
- KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. 2013
- KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. 2013
- Potential Impact of miR-137 and Its Targets in Schizophrenia.. Frontiers in genetics. 4:-. 2013
- Role of HuD in nervous system function and pathology.. Frontiers in bioscience (Scholar edition). 5:554-563. 2013
- Medial-frontal cortex hypometabolism in chronic phencyclidine exposed rats assessed by high resolution magic angle spin 11.7 T proton magnetic resonance spectroscopy.. Neurochemistry international. 61:128-131. 2012
- RNA-binding protein HuD controls insulin translation.. Molecular cell. 45:826-835. 2012
- Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice. 2011
- Source-based morphometry analysis of group differences in fractional anisotropy in schizophrenia.. Brain connectivity. 1:133-145. 2011
- Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets.. Nucleic acids research. 38:117-130. 2010
- Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.. Human brain mapping. 30:241-255. 2009
- Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.. NeuroImage. 46:809-816. 2009
- Prenatal ethanol exposure persistently impairs NMDA receptor-dependent activation of extracellular signal-regulated kinase in the mouse dentate gyrus. 2009
- Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine.. Neurochemistry international. 55:775-782. 2009
- Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.. Hippocampus. 18:814-823. 2008
- Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients.. The American journal of psychiatry. 165:1594-1603. 2008
- Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. 2008
- Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity. 2007
- The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy. 2007
- Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 31:751-756. 2006
- In vivo post-transcriptional regulation of GAP-43 mRNA by overexpression of the RNA-binding protein HuD.. Journal of neurochemistry. 96:790-801. 2006
- Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia.. The American journal of psychiatry. 163:1829-1831. 2006
- Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia.. Progress in neuro-psychopharmacology & biological psychiatry. 29:283-290. 2005
- Altered myelination of the hippocampal formation in subjects with schizophrenia and bipolar disorder. 2004
- Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learning.. Neuroscience letters. 371:152-157. 2004
- Fetal alcohol exposure alters GAP-43 phosphorylation and protein kinase C responses to contextual fear conditioning in the hippocampus of adult rat offspring.. Alcoholism, clinical and experimental research. 28:113-122. 2004
- Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring.. Alcoholism, clinical and experimental research. 28:1587-1597. 2004
- Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration.. Experimental neurology. 183:100-108. 2003
- Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD.. The Journal of biological chemistry. 277:27996-28002. 2002
- Role of HuD and other RNA-binding proteins in neural development and plasticity. 2002
- Prenatal ethanol exposure decreases GAP-43 phosphorylation and protein kinase C activity in the hippocampus of adult rat offspring.. Journal of neurochemistry. 71:2104-2111. 1998
- Alterations in GAP-43-immunoreactive innervation in the aging rat pituitary.. Neuroscience letters. 208:138-142. 1996
- Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia.. Proceedings of the National Academy of Sciences of the United States of America. 93:14182-14187. 1996
- GAP-43-Immunoreactive Nerve Fibers in the Rat Pituitary: Modulation after 6-Hydroxydopamine-Induced Degeneration and Regeneration.. Molecular and cellular neurosciences. 4:576-582. 1993
- Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA.. The Journal of cell biology. 120:1263-1270. 1993
- Effects of moderate drinking during pregnancy on placental gene expression.. Alcohol (Fayetteville, N.Y.). 44:673-690.
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article
- Biological mechanisms of schizophrenia. wiley Encyclopedia of Chemical biology. 2008
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chapter
- GAP-43 in Neural Development and Plasticity. Handbook of Neurochemistry and Molecular Neurobiology. Springer-Verlag. 315-329. 2006
- Post-transcriptional regulation of the GAP-43 gene. RNA Binding Proteins. New York: Springer Berlin Heidelberg. 157-175. 2002
Research
research overview
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Post-transcriptional control of addiction-related genes and behavior induced by cocaine and other drugs of abuse
Potential use of serum microRNAs as biomarkers of drug exposure or abuse
Background
education and training
- Ph.D., University of Buenos Aires, Argentina , Biochemistry 1984
- B.S., University of Buenos Aires 1980
- Harvard Medical School , Neuroscience 1984 - 1986
awards and honors
- Fitz List, 2014
- Fellow of the American Association for the Advancement of Science, conferred by AAAS, 2011
- A. Earl Walker Neuroscience award, conferred by University of New Mexico School of Medicine, 2011
- Scottish Rite Schizophrenia Research Program Award, 1988
- Gold Medal Award for best qualifications in Biochemistry, conferred by U.B.A, 1981
- Lavoisier Award for best qualifications in Chemistry, conferred by U.B.A, 1980
- Regent Lectureship Award, conferred by University of New Mexico, 1993 - 1995
- Fellow, National Council for Scientific and Technical Research, 1980 - 1984
Contact
full name
- Nora Perrone-Bizzozero