Two-year outcomes in first-episode psychotic depression the McLean-Harvard First-Episode Project. Academic Article uri icon

start page

  • 1

end page

  • 8

abstract

  • Early assessment can guide accurate diagnosis, prognosis, and treatment-planning for patients with major mental illnesses. Longitudinal studies in psychotic depression from onset are rare, encouraging the present study.We followed 56 DSM-IV MDD patients with psychotic features prospectively and systematically to assess course and predictors of operationally-defined syndromal remission, syndromal recovery, symptomatic remission, functional recovery, and new episodes, and to evaluate diagnostic stability.Among 49/56 cases followed for ≥2 years, 59% retained the initial diagnosis and most achieved syndromal remission (86%) and recovery (84%); 58% remitted symptomatically, and only 35% (17/49) recovered functionally. Syndromal recovery was earlier following subacute onset, lower initial depression scores, and lack of moodincongruent psychotic features. Within 2 years, 45% (22/49) experienced new episodes - earlier with younger onset and higher CGI scores. DSM diagnosis changed in 41%, to bipolar (33%), or schizoaffective disorders (12%), which followed early mania-like or schizophrenia-like features, respectively.Within 2 years of first-hospitalizations, 41% of patients initially diagnosed with psychotic-depression met criteria for DSM-IV bipolar or schizoaffective disorders. Of the 59% retaining the initial diagnosis for 2 years, nearly half experienced new episodes, 42% remained symptomatic, and two-thirds failed to regain their own prior functional status.Copyright © 2011 Elsevier B.V. All rights reserved.

date/time value

  • January 2012

Digital Object Identifier (DOI)

  • 10.1016/j.jad.2011.08.028

PubMed Identifier

  • 21943929

volume

  • 136

number

  • 1-2

keywords

  • Adolescent
  • Adult
  • Aged
  • Bipolar Disorder
  • Depressive Disorder, Major
  • Female
  • Hospitalization
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prognosis
  • Psychotic Disorders
  • Young Adult