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Pinchuk, Iryna V Assistant Professor

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Assistant Professor: Division of Gastroenterology and Hetapology, University of Texas Medical Branch

Dr. Iryna Pinchuk is currently an Assistant Professor in the Division of Gastroenterology and Hepatology in the Department of Internal Medicine at The University of Texas Medical Branch (UTMB) in Galveston. She earned her PhD degree in Food and Biological Sciences from the University of Bordeaux I located in Talence, France. She then did postdoctoral fellowship at UT Health Center at Tyler, Texas and at UTMB at Galveston, Texas. Dr. Pinchuk's research during her postdoctoral fellowship at UTMB was supported by Crohn's & Colitis Foundation of America. She was promoted to Assistant Professor 2009. Her current research is supported by the American Gastroenterological Association (AGA Research Scholarship Award 2009-2011). Dr Pinchuk is co-author of a patent and has co-authored over 25 peer-reviewed journal articles and reviews.

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selected publications

academic article
- Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn's Disease and Determines Their Capacity to Suppress Th1 Cells.. Frontiers in immunology. 9:-. 2018
- MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth.. Frontiers in immunology. 9:-. 2018
- Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens.. Journal of visualized experiments : JoVE. :-. 2016
- CD90(+) stromal cells are the major source of IL-6 which supports cancer stem-like cells and inflammation in colorectal cancer.. International journal of cancer. Journal international du cancer. :-. 2015
- Blockade of MK2 is protective in inflammation-associated colorectal cancer development.. International journal of cancer. Journal international du cancer. :-. 2015
- Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses.. Oncotarget. :-. 2015
- TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.. Journal of immunology (Baltimore, Md. : 1950). 193:2218-2229. 2014
- G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration.. British journal of cancer. 110:1211-1220. 2014
- Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers. PLOS One . 9:-. 2014
- G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. British journal of cancer. 110:1211-1220. 2014
- TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. Journal of Immunology. 193:2218-2229. 2014
- Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment. PLOS One . 8:53798. 2013
- Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment. 2013
- Inflammation, immunity, and vaccines for Helicobacter pylori infection.. Helicobacter. 17 Suppl 1:16-21. 2012
- Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.. Gastroenterology. 140:2019-2030. 2011
- Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection.. Infection and immunity. 79:2737-2745. 2011
- PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.. Gastroenterology. 135:1228-1237, 1237.e1-2. 2008
article
- G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. British journal of cancer. 110:1211-1220. 2014