selected publications
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academic article
- Epigenetic silencing of SOCS5 potentiates JAK-STAT signaling and progression of T-cell acute lymphoblastic leukemia.. Cancer Sciecne. 110:1931-1946. 2019
- Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.. Leukemia. 32:2126-2137. 2018
- High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL.. SLAS Discovery. 23:732-741. 2018
- Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children's oncology group (COG) clinical trials.. Leukemia & lymphoma. 59:1624-1633. 2018
- Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL.. Biomarker research. 6:-. 2018
- Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 129:177-187. 2017
- Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. 2016
- Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.. Nature communications. 7:-. 2016
- Characterization of leukemias with ETV6-ABL1 fusion.. Haematologica. 101:1082-1093. 2016
- MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: A children's oncology group study.. Leukemia. :-. 2016
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.. Cancer cell. 29:186-200. 2016
- Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434. 2015
- Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children's Oncology Group study AALL0232.. Blood. :-. 2015
- Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.. Nature. 521:357-361. 2015
- Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia.. Molecular cancer therapeutics. 14:364-374. 2015
- A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. 2015
- Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.. Nature communications. 6:-. 2015
- Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. 2014
- Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.. Blood. 121:485-488. 2013
- ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30:751-757. 2012
- Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.. Blood. 120:833-842. 2012
- Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.. Cancer cell. 22:153-166. 2012
- Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.. Blood. 120:4197-4204. 2012
- High-throughput sequencing detects minimal residual disease in acute T lymphoblastic leukemia.. Science translational medicine. 4:-. 2012
- Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.. Blood. 119:3512-3522. 2012
- Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.. Blood. 120:3510-3518. 2012
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.. Nature. 481:157-163. 2012
- Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.. Nature genetics. 43:237-241. 2011
- Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.. Blood. 118:3080-3087. 2011
- Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28:3816-3823. 2010
- JAK mutations in high-risk childhood acute lymphoblastic leukemia.. Proceedings of the National Academy of Sciences of the United States of America. 106:9414-9418. 2009