Brigman, Jonathan

head of

Brigman Lab Principal Investigator

member of

Fetal Alcohol Spectrum Disorders Study Group Member 2015 -
Center for Brain Recovery and Repair Preclinical Core Associate Director 2014 -
New Mexico Alcohol Research Center Component PI 2014 -
Research Society on Alcoholism Member 2013 -
International Behavioral Neuroscience Society Member 2008 -
Society for Neuroscience Member 2004 -
Psi Chi, The International Honor Society in Psychology Member 1998 -

selected publications

academic article
- Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes.. Science translational medicine. 12:-. 2020
- Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.. NPJ vaccines. 4:-. 2019
- Amphetamine improves mouse and human attention in the 5-choice continuous performance test. Neuropharmacology. 138:87-96. 2018
- Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm. Neurobiology of learning and memory. 2018
- Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats. 2018
- Extended erythropoietin treatment prevents chronic executive functional and microstructural deficits following early severe traumatic brain injury in rats. . Frontiers in Neurology. 9:1-12. 2018
- Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning. . Neurobiology of learning and memory. 2018
- Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior. . Genes, Brain and Behavior. 17:1-10. 2018
- Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response. . Neuroscience letters. 683:119-124. 2018
- Touch-screen visual reversal learning is mediated by value encoding and signal propagation in the orbitofrontal cortex.. Neurobiology of learning and memory. 139:179-188. 2017
- The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models.. Alcohol (Fayetteville, N.Y.). 51:1-15. 2016
- The neural basis of reversal learning: An updated perspective.. Neuroscience. :-. 2016
- Loss of hippocampal function impairs pattern separation on a mouse touch-screen operant paradigm.. Neurobiology of learning and memory. 125:85-92. 2015
- Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant mice.. Neuroreport. 26:489-494. 2015
- Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.. Genes, brain, and behavior. 14:4-21. 2015
- Conditional loss of GluN2B in cortex and hippocampus impairs attentional set formation. Behavioral Neuoscience. 2015
- Loss of GluN2A-containing NMDA receptors impairs extra-dimensional set-shifting.. Genes, brain, and behavior. 13:611-617. 2014
- Prenatal ethanol exposure impairs executive function in mice into adulthood. Alcoholism, clinical and experimental research. 2014
- Chronic alcohol produces neuroadaptations to prime dorsal striatal learning. 2013
- GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state.. Endocrinology. 154:4136-4145. 2013
- GluN2B in corticostriatal circuits governs choice learning and choice shifting.. Nature neuroscience. 16:1101-1110. 2013
- Examining the genetic and neural components of cognitive flexibility using mice.. Physiology & behavior. 107:666-669. 2012
- Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF.. Nature neuroscience. 14:1507-1509. 2011
- Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. 2010
- Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice.. Cerebral cortex (New York, N.Y. : 1991). 20:1955-1963. 2010
- Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia.. Frontiers in neuroscience. 4:-. 2010
- Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.. Frontiers in behavioral neuroscience. 3:-. 2009
- Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit.. Learning & memory (Cold Spring Harbor, N.Y.). 15:50-54. 2008
- Stimulus specific deficit on visual reversal learning after lesions of medial prefrontal cortex in the mouse.. Behavioural brain research. 187:405-410. 2008

research overview

The focus of our research is to further our understanding of the maladaptive behavioral changes that accompany alcohol abuse , drug addiction and numerous neuropsychiatric disorders. Current theories have proposed that early or repeated alcohol exposure can lead to progressive loss of cortically-mediated executive control. As top-top down control is lost, habitual alcohol or drug seeking comes to dominate the behavioral repertoire leading to decreased quality of life. If this maladaptive shift in behavior could be prevented or reversed, it would provide an important therapeutic tool for combating addiction. Our research focuses on developing models that allow us to investigate the role of both genetic factors and molecular mechanisms in mediating executive control behaviors, both before and after drug and alcohol exposure. One potential mechanism of interest due to its established role in the neuro-plasticity underlying learning and memory is the glutamatergic N-methyl-D-aspartate receptor (NMDAR). We are currently exploring how NMDAR subunit composition and receptor expression is altered by alcohol exposure. Another major focus of the lab is understanding the optimal organization of neuronal firing in corticostriatal circuits in vivo, and how alterations in NMDAR may disrupt these patterns, leading to loss of executive control and poorer functional outcome.

principal investigator on

investigator on

4UH3-MH109168-03 Novel Assays to Address Translational Gaps in Treatment Development 2018 - 2020

teaching activities

BIOM 509 Introduction to Neurobiology Course Instructor 2019 -
BIOM 509 Introduction to Neurobiology Instructor: Executive Control & Substance Abuse Modules
BIOM 533 Neurophysiology/Neuroanatomy Instructor: Learning and Memoryl & Substance Abuse Modules
Phase I Neuroscience Instructor for Neuroanatomy and Small Group Tutor

advisees

graduate advising relationship
- Olguin , Sarah, Ph.D. candidate, 2016 -
- Kenton, Johnny, Ph.D. candidate, 2015 -
- Floruta, Crina , Ph.D. candidate, 2015 -
- Zimmerman, Amber, Ph.D. candidate, 2016 -
- Chandrasekaran, Jayapriya, Ph.D. candidate, 2018 -
- Oliver, Robert, Ph.D. candidate, 2012 - 2018
- Marquardt, Kristin, Ph.D. candidate, 2013 - 2017
- Rice, James, Ph.D. candidate, 2012 - 2013
undergraduate advising relationship
- Thompson, Shannon, B.S. candidate, 2013 - 2017
Saha, Monica, 2012 - 2013

organizer of event

New Mexico EEG and Behavior Conference 2018 -

professional service activities

Society for Neuroscience Trainee Professional Development Awards Committee 2017 -
International Behavioral Neuroscience Society Chair, Education & Training Committee 2013 - 2015
International Behavioral Neuroscience Society Member, Program Commitee 2013 - 2015

full name

Jonathan Brigman

VIVO

Brigman, Jonathan Faculty Member

Positions

Research Areas

Affiliation

head of

member of

Publications

selected publications

academic article

Research

research overview

principal investigator on

investigator on

Teaching

teaching activities

advisees

graduate advising relationship

undergraduate advising relationship

Service

organizer of event

professional service activities

outreach and community service activities

Background

education and training

awards and honors

Contact

full name