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• Contact Info

• AGardiner@salud.unm.edu

• 505-272-2249

• Websites

• Amy S. Gardiner

Publications in VIVO

 

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Gardiner, Amy S. Assistant Professor

My lab studies novel molecular mechanisms of small RNA-mediated gene regulation in neuronal development and cancer.

Research Areas

• Brain Cancer
• Neovascularization inhibitors (LCSH)

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• Affiliation
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• Publications
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• Research
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• Teaching
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• Background
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• Contact
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Affiliation

head of

• Gardiner Lab Principal Investigator 2018 -

member of

• UNM Comprehensive Cancer Center Associate Member 2016 -

Publications

selected publications

• academic article

  • Inhibition of MiR-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.  J Am Heart Assoc.  2018
  • Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding..  Journal of cell science.  130:3650-3662. 2017
  • Axonal Localization of Neuritin/CPG15 mRNA is Limited by Competition for HuD Binding.  J Cell Sci.  130:3650. 2017
  • In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens..  Molecular psychiatry.  :-. 2017
  • Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum..  Alcoholism, clinical and experimental research.  40:826-837. 2016
  • Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum..  Alcoholism, clinical and experimental research.  40:826-837. 2016
  • Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function..  Biomolecules.  5:2903-2918. 2015
  • Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1..  Nucleic acids research.  43:7432-7446. 2015
  • Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1..  Nucleic acids research.  43:7432-7446. 2015
  • Competing Interactions of RNA-Binding Proteins, MicroRNAs, and their Targets Control Neuronal Development and Function.  Biomolecules.  5:2903. 2015
  • Overexpression of miR-495 in nucleus accumbens attenuates cocaine intake on a progressive ratio schedule of reinforcement.  Drug Alcohol Depend.  146:e219. 2015
  • Beyond irrelevant actions: understanding the role of intentionality in children's imitation of relevant actions..  Journal of experimental child psychology.  119:54-72. 2014
  • KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. 2013
  • KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. 2013
  • MicroRNA Analysis in Human Papillomavirus (HPV)-Associated Cervical Neoplasia and Cancer.  J Carcinogene and Mutagene.  2:114. 2011
  • Human Papillomavirus Type 16 Reduces the Expression of MicroRNA-218 in Cervical Carcinoma Cells.  Oncogene.  27:2575. 2008
  • Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide..  International immunology.  19:1103-1113. 2007
  • A primary healthcare approach to the management of chronic disease in Ethiopia: an example for other countries..  Clinical medicine (London, England).  7:228-231. 2007
  • Conformation of MHC Class II I-Ag7 is Sensitive to the P9 Anchor Amino Acid in Bound Peptide.  Int Immunol.  19:1103. 2007

• chapter

  • Alterations in Cellular MiRNAs Induced by Human Papillomaviruses.  Small DNA Tumor Viruses. Ed. Gaston, Kevin.  Norfolk. U.K.: Horizon Scientific and Caister Academic Press. 2011

Research

research overview

• My research is focused on understanding the role of non-coding RNAs and RNA-binding proteins (RBPs) in neuronal development, substance abuse, and cancer. Small non-coding RNAs, such as microRNAs (miRNAs), and RBPs post-transcriptionally control the expression of a vast number of neuronal genes through the regulation mRNA splicing, stability, localization, and translation. Many miRNAs and RBPs are therefore considered to be master regulators of gene expression. Much of my work has concentrated on defining the regulatory regions and mechanisms that direct these processes. Current projects in my lab involve uncovering novel mechanisms of small RNA-mediated regulation of gene expression, examining miRNA-mediated pathways during cortical vascular development, and investigating the role of both small and long non-coding RNAs in glioblastoma multiforme.
  
  1. miR-150 is a well-characterized miRNA that is expressed in the brain, and specifically in endothelial cells, during development. miR-150 is a known regulator of angiogenesis, and it is upregulated in the developing cortex in our model of prenatal alcohol exposure. We are working to identify angiogenic targets of miR-150 and to determine its effect on the developing cortical vasculature during prenatal alcohol exposure.
  
  2. KSRP is an RBP whose expression is significantly associated with prolonged survival of glioblastoma patients. We have identified novel KSRP-regulated miRNA and long non-coding RNA targets in the cortex. Ongoing studies are aimed at understanding how KSRP interacts with and regulates its various targets in glioblastoma cells and elucidating its tumor suppressive effect in a genetically engineered mouse model of glioblastoma.

principal investigator on

• The role of miR-150-5p in regulating angiogenesis during prenatal alcohol exposure 2018 - 2020
• Assessing miRNA-mediated vascular dysfunction in mice prenatally exposed to alcohol 2018 - 2019
• Altering KSRP in a genetically engineered mouse model of glioblastoma 2017 - 2018
• KSRP and KSRP-regulated non-coding RNAs in glioblastoma 2016 - 2017

keywords

• microRNA
  long non-coding RNA
  RNA-binding protein
  neurovascular development
  substance abuse
  glioblastoma multiforme

Teaching

teaching overview

• RNA Biology

teaching activities

• BIOM 507/525 Lecturer 2018 -

Background

education and training

• Ph.D., University of Pittsburgh School of Medicine, Pittsburgh, PA 2004 - 2010
• M.S., American University 2002 - 2004
• B.S., Loyola University New Orleans 1996 - 1999
• 2011 - 2018

Contact

full name

• Amy S. Gardiner

mailing address

• 1 University of New Mexico

  MSC08 4750

  Albuquerque, NM  87131

  USA

geographic location

• Office: Fitz 157, Lab: Fitz 171 

located in facility

• Fitz Hall