Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. Academic Article uri icon

start page

  • 355

end page

  • 356

abstract

  • Atendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to schizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year 1 followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

date/time value

  • October 2007

Digital Object Identifier (DOI)

  • 10.1192/bjp.bp.106.031195

PubMed Identifier

  • 17906248

volume

  • 191

number

keywords

  • Delusions
  • Disease Progression
  • Humans
  • Neuropsychological Tests
  • Noise
  • Predictive Value of Tests
  • Risk Factors
  • Schizophrenia
  • Schizophrenic Psychology
  • Speech Perception